Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2609708 | 0.82 | CA12 (0.47) | HCAR2KEAP1NFE2L2ALDH1A1POLB | |
| SCHEMBL19701744 | 0.82 | HCAR2 (0.43) | HCAR2KEAP1NFE2L2ALDH1A1MEN1 | |
| SCHEMBL196620 | 0.79 | HCAR2 (0.43) | HCAR2KEAP1NFE2L2ALDH1A1MEN1 | |
| SCHEMBL2609719 | 0.79 | HCAR2 (0.37) | HCAR2KEAP1NFE2L2ALDH1A1MEN1 | |
| SCHEMBL2609707 | 0.79 | HCAR2 (0.37) | HCAR2KEAP1NFE2L2ALDH1A1MEN1 | |
| SCHEMBL15490807 | 0.76 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2ALDH1A1MEN1 | |
| SCHEMBL2616187 | 0.74 | ALDH1A1 (0.41) | HCAR2KEAP1NFE2L2ALDH1A1POLB | |
| SCHEMBL2609697 | 0.73 | HCAR2 (0.52) | HCAR2KEAP1NFE2L2ALDH1A1MEN1 | |
| SCHEMBL4456360 | 0.71 | HCAR2 (0.54) | HCAR2KEAP1NFE2L2ALDH1A1POLB | |
| SCHEMBL4456361 | 0.71 | HCAR2 (0.54) | HCAR2KEAP1NFE2L2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157523-A1 | PRODRUGS OF METHYL HYDROGEN FUMARATE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | XENOPORT, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157523-A1 | PRODRUGS OF METHYL HYDROGEN FUMARATE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | FH, MGMT, BHMT2 | HCAR2 70/4885KEAP1 2571/4885NFE2L2 2133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.