Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10588609 | 0.86 | LMNA (0.47) | GSTP1GSTM2KMT2AALDH1A1MEN1 | |
| SCHEMBL24879108 | 0.86 | KDM4E (0.43) | KMT2AALDH1A1MEN1GAAHSD17B10 | |
| SCHEMBL15123545 | 0.80 | ABL1 (0.48) | GSTP1GSTM2KMT2AALDH1A1MEN1 | |
| SCHEMBL30660933 | 0.78 | KMT2A (0.43) | GSTP1GSTM2KMT2AALDH1A1MEN1 | |
| SCHEMBL18320494 | 0.78 | KMT2A (0.43) | GSTP1GSTM2KMT2AALDH1A1MEN1 | |
| SCHEMBL23977089 | 0.77 | MAPT (0.46) | GSTP1GSTM2KMT2AALDH1A1MEN1 | |
| SCHEMBL25300713 | 0.75 | PTGS2 (0.33) | KMT2AALDH1A1MEN1GAA | |
| SCHEMBL29506060 | 0.74 | KMT2A (0.45) | GSTP1GSTM2KMT2AALDH1A1MEN1 | |
| SCHEMBL18319841 | 0.74 | KMT2A (0.45) | GSTP1GSTM2KMT2AALDH1A1MEN1 | |
| SCHEMBL24635805 | 0.74 | GSTP1 (0.38) | GSTP1GSTM2KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4108659-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | Jacobio Pharmaceuticals Co., Ltd. (CN) | 2022-12-28 | — | — | EP | disclosed |
| US-10858359-B2 | Heterocyclic ring derivatives useful as SHP2 inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2020-12-08 | — | — | US | disclosed |
| US-20190127378-A1 | NOVEL HETEROCYCLIC RING DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2019-05-02 | — | — | US | disclosed |
| WO-2017211303-A1 | NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2017-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858359-B2 | Heterocyclic ring derivatives useful as SHP2 inhibitors | PTPRJ, PTPN22, PTPRCAP | GSTP1 1709/4885GSTM2 1578/4885KMT2A 1311/4885 |
| US-20190127378-A1 | NOVEL HETEROCYCLIC RING DERIVATIVES USEFUL AS SHP2 INHIBITORS | PTPN22, PTPN1, PTPRJ | GSTP1 2380/4885GSTM2 2632/4885KMT2A 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.