Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.55 |
| ▸ | ITGAV | P06756 | 6/20 | 0.55 |
| ▸ | THRB | P10828 | 9/20 | 0.54 |
| ▸ | THRA | P10827 | 7/20 | 0.54 |
| ▸ | PPARG | P37231 | 5/20 | 0.54 |
| ▸ | RXRA | P19793 | 3/20 | 0.54 |
| ▸ | PCNA | P12004 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19677575 | 0.87 | ITGB3 (0.61) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL19708683 | 0.87 | THRB (0.57) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL19677591 | 0.79 | ITGB3 (0.71) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL23984251 | 0.77 | ITGB3 (0.52) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL24063119 | 0.76 | THRB (0.47) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL19696744 | 0.73 | THRB (0.76) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL19677585 | 0.72 | ITGB3 (0.53) | ITGB3ITGAVTHRBTHRAPPARG | |
| Tetrac SCHEMBL365951 | 0.71 | THRB (1.00) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL12764500 | 0.71 | THRB (0.68) | ITGB3ITGAVTHRBTHRAPPARG | |
| SCHEMBL16155956 | 0.71 | THRB (0.68) | ITGB3ITGAVTHRBTHRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017214299-A1 | NON-CLEAVABLE POLYMER CONJUGATED WITH αvβ3 INTEGRIN THYROID ANTAGONISTS | NANOPHARMACEUTICALS, LLC (US) | 2017-12-14 | — | — | WO | disclosed |