Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29634956 | 0.93 | BLM (0.53) | BLMPMP22KMT2AALOX15MDM2 | |
| SCHEMBL5057390 | 0.83 | MDM2 (0.41) | BLMPMP22MDM2L3MBTL1MAPT | |
| SCHEMBL1969120 | 0.83 | L3MBTL1 (0.41) | BLMPMP22MDM2L3MBTL1MAPT | |
| SCHEMBL28121840 | 0.82 | KMT2A (0.42) | BLMPMP22KMT2AALOX15MDM2 | |
| SCHEMBL4658683 | 0.81 | BLM (0.47) | BLMPMP22KMT2AALOX15L3MBTL1 | |
| SCHEMBL4658680 | 0.81 | BLM (0.47) | BLMPMP22KMT2AALOX15L3MBTL1 | |
| SCHEMBL12698767 | 0.81 | CYP1A2 (0.52) | MDM2L3MBTL1MAPTTDP1TSHR | |
| SCHEMBL5495906 | 0.80 | MDM2 (0.43) | BLMPMP22KMT2AALOX15MDM2 | |
| SCHEMBL4751891 | 0.78 | ANPEP (0.44) | MDM2L3MBTL1TDP1LMNACES2 | |
| SCHEMBL29029660 | 0.78 | MDM2 (0.53) | BLMPMP22KMT2AALOX15MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177530-B1 | Octapeptide having antiangiogenic activity | ABBOTT LAB (US) | 2011-06-22 | — | — | EP | disclosed |
| EP-2177530-A1 | Octapeptide having antiangiogenic activity | Abbott Laboratories (US) | 2010-04-21 | — | — | EP | disclosed |
| US-20080071062-A1 | TETRA-, PENTA-, HEXA- AND HEPTAPEPTIDES HAVING ANTIANGIOGENIC ACTIVITY | HAVIV FORTUNA | 2008-03-20 | — | — | US | disclosed |
| US-20070167376-A1 | Hexa-, Hepta-, and Octapeptides Having Antiangiogenic Activity | HAVIV FORTUNA | 2007-07-19 | — | — | US | disclosed |
| US-7169888-B2 | Tetra-, penta-, hexa- and heptapeptides having antiangiogenic activity | ABBOTT LABORATORIES (US) | 2007-01-30 | — | — | US | disclosed |
| US-7122625-B2 | Hexa-, hepta-, and octapeptides having antiangiogenic activity | ABBOTT LABORATORIES (US) | 2006-10-17 | — | — | US | disclosed |
| US-20060194737-A1 | Hepta-, octa-and nonapeptides having antiangiogenic activity | HAVIV FORTUNA | 2006-08-31 | — | — | US | disclosed |
| US-7067490-B2 | Hepta-, Octa-and nonapeptides having antiangiogenic activity | ABBOTT LABORATORIES (US) | 2006-06-27 | — | — | US | disclosed |
| US-7037897-B2 | TRI-, TETRA-, and penta-peptides having antiangiogenic activity | ABBOTT LABORATORIES (US) | 2006-05-02 | — | — | US | disclosed |
| US-7001984-B2 | Di-, tri-, and tetra-peptides having antiangiogenic activity | ABBOTT LABORATORIES (US) | 2006-02-21 | — | — | US | disclosed |
| EP-1232183-B1 | PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LAB (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20050215484-A1 | Di-, tri-, and tetra-peptides having antiangiogenic activity | HAVIV FORTUNA | 2005-09-29 | — | — | US | disclosed |
| US-6777535-B1 | USEFUL FOR TREATING CONDITIONS WHICH ARISE OR ARE EXACERBATED BY ANGIOGENESIS | ABBOTT LABORATORIES | 2004-08-17 | — | — | US | disclosed |
| US-6753408-B1 | DRUGS USED FOR THERAPY | ABBVIE INC. | 2004-06-22 | — | — | US | disclosed |