Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19690863 | 0.86 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1HTTEGFRPOLB | |
| SCHEMBL19691065 | 0.85 | HTT (0.43) | SMN1; SMN2ALDH1A1HTTADORA2AADORA1 | |
| SCHEMBL19708905 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1HTTEGFRADORA2A | |
| SCHEMBL19690935 | 0.77 | FPR2 (0.45) | SMN1; SMN2HTTADORA2AADORA1KDM4E | |
| SCHEMBL19690860 | 0.77 | HTT (0.43) | SMN1; SMN2ALDH1A1HTTADORA2AADORA1 | |
| SCHEMBL19700431 | 0.77 | ROCK2 (0.39) | SMN1; SMN2MAPTGAA | |
| SCHEMBL19691077 | 0.77 | ROCK2 (0.39) | SMN1; SMN2MAPTGAA | |
| SCHEMBL19691033 | 0.75 | KDM4E (0.36) | SMN1; SMN2ALDH1A1HTTADORA2APOLB | |
| SCHEMBL19686373 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1HTTEGFRADORA2A | |
| SCHEMBL21166229 | 0.73 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1HTTEGFRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355708-A1 | POTASSIUM CHANNEL MODULATORS | CADENT THERAPEUTICS, INC. | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355708-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | SMN1; SMN2 841/4885ALDH1A1 1315/4885HTT 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.