Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | LTA4H | P09960 | 3/20 | 0.47 |
| ▸ | MPL | P40238 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480736 | 0.87 | MAPT (0.68) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL27985361 | 0.87 | LTA4H (0.54) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL22290249 | 0.79 | RAB9A (0.58) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL17407196 | 0.79 | LTA4H (0.55) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL17407200 | 0.79 | ALDH1A1 (0.58) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL17549001 | 0.77 | LTA4H (0.53) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL474188 | 0.77 | MAPT (0.55) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| Bromide SCHEMBL8360770 | 0.76 | MAPT (0.54) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL17386917 | 0.75 | RAB9A (0.44) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1689576 | 0.75 | RAB9A (0.66) | MAPTMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9844549-B2 | 2-aminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2017-12-19 | — | — | US | disclosed |