SCHEMBL19721887

SCHEMBL19721887

COc1ccc(-c2ccc(C3CCC(CCF)CC3)cc2)c(C)c1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 2/20 0.39
CASR P41180 1/20 0.38
DGAT1 O75907 2/20 0.37
SOAT1 P35610 1/20 0.37
ESR2 Q92731 1/20 0.37
MAOB P27338 5/20 0.36
CYP26A1 O43174 1/20 0.36
CYP24A1 Q07973 1/20 0.36
DRD2 P14416 1/20 0.36
CRHR1 P34998 2/20 0.36
CYP3A4 P08684 1/20 0.36
CYP19A1 P11511 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
FFAR4 Q5NUL3 1/20 0.35
CYP2C9 P11712 1/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPK1 P28482 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13614287 0.86 CYP2C9 (0.41) MCHR1CASRDGAT1SOAT1ESR2
SCHEMBL21321657 0.86 DRD2 (0.40) MCHR1CASRESR2DRD2CRHR1
SCHEMBL19722140 0.85 DRD2 (0.39) MCHR1CASRESR2DRD2CRHR1
SCHEMBL19721876 0.82 DGAT1 (0.36) DGAT1SOAT1ESR2CYP3A4FFAR4
SCHEMBL19721960 0.81 FFAR4 (0.39) CASRDGAT1SOAT1ESR2CYP24A1
SCHEMBL12769087 0.80 DRD2 (0.43) CASRMAOBDRD2SMN1; SMN2CYP2C9
SCHEMBL13614363 0.79 DRD2 (0.42) CASRMAOBDRD2FFAR4
SCHEMBL13614297 0.79 DRD2 (0.40) DGAT1DRD2CYP2C9MEN1ALDH1A1
SCHEMBL21321653 0.78 CYP2C9 (0.41) DGAT1SOAT1ESR2CYP3A4CYP2C9
SCHEMBL19722086 0.77 DRD2 (0.43) DGAT1ESR2MAOBDRD2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3257839-A1 POLYMERIZABLE POLAR COMPOUND, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT JNC Corporation (JP) 2017-12-20 EP disclosed