Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | SPR | P35270 | 2/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12821125 | 0.86 | CREBBP (0.50) | NAMPTBRD4CREBBPSPRHPGDS | |
| SCHEMBL29573372 | 0.78 | NAMPT (0.40) | NAMPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31613473 | 0.77 | NAMPT (0.46) | NAMPTCREBBPNR1H2PDK2SPR | |
| SCHEMBL26077184 | 0.74 | KRAS (0.38) | NAMPTNR1H2PDK2 | |
| SCHEMBL21765690 | 0.73 | BLM (0.43) | NAMPTHPGDSCHRNB2CHRNA3CHRNA4 | |
| SCHEMBL6110578 | 0.72 | LMNA (0.47) | NAMPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4794247 | 0.71 | CREBBP (0.36) | NAMPTBRD4CREBBPHPGDSCHRNB2 | |
| SCHEMBL14970400 | 0.71 | NOTUM (0.50) | NAMPTBRD4CREBBPSPR | |
| SCHEMBL9944478 | 0.71 | SPR (0.43) | NAMPTBRD4CREBBPNR1H2PDK2 | |
| SCHEMBL13373469 | 0.71 | SPR (0.43) | NAMPTBRD4CREBBPSPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780337-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS | MERCK SHARP & DOHME (US) | 2017-12-20 | — | — | EP | disclosed |