Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8681014 | 0.82 | ALDH1A1 (0.39) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL9917550 | 0.79 | HSD17B10 (0.43) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL26289831 | 0.77 | KDM4E (0.35) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL8870392 | 0.76 | ALDH1A1 (0.35) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL8680618 | 0.74 | ADRA1D (0.40) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL26289822 | 0.73 | ALDH1A1 (0.32) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL28559831 | 0.73 | HPGD (0.36) | ALDH1A1HSD17B10TSHRTDP1KDM4E | |
| SCHEMBL30612722 | 0.72 | ALDH1A1 (0.46) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL8681961 | 0.72 | ALDH1A1 (0.46) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 | |
| SCHEMBL4625971 | 0.72 | HTR2C (0.36) | ALDH1A1HSD17B10TSHRCYP2A6TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8029696-B2 | Fused naphthalenes | MERCK PATENT GMBH (DE) | 2011-10-04 | — | — | US | disclosed |
| EP-2044172-B1 | FUSED NAPHTHALENES | MERCK PATENT GMBH (DE) | 2011-06-22 | — | — | EP | disclosed |
| US-20100059711-A1 | FUSED NAPHTHALENES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-03-11 | — | — | US | disclosed |
| EP-2044172-A1 | FUSED NAPHTHALENES | Merck Patent GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008012180-A9 | FUSED NAPHTHALENES | MERCK PATENT GMBH (DE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2008012180-A1 | FUSED NAPHTHALENES | MERCK PATENT GMBH (DE) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100059711-A1 | FUSED NAPHTHALENES | CCNE2, CCNE1, F12 | ALDH1A1 1986/4885HSD17B10 2258/4885TSHR 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.