Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL339492 | 0.84 | ALOX15 (0.81) | ALOX15ALDH1A1FFAR1SMN1; SMN2PTPN7 | |
| Water SCHEMBL28773724 | 0.82 | ALOX15 (0.95) | ALOX15ALDH1A1FFAR1SMN1; SMN2PTPN7 | |
| SCHEMBL3805601 | 0.81 | ALOX15 (0.44) | ALOX15ALDH1A1FFAR1SMN1; SMN2KMT2A | |
| SCHEMBL196312 | 0.81 | MEN1 (0.46) | ALOX15ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3169853 | 0.81 | ALOX15 (0.42) | ALOX15ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL10778419 | 0.81 | ALOX15 (0.42) | ALOX15ALDH1A1FFAR1SMN1; SMN2PTPN7 | |
| SCHEMBL8127 | 0.79 | ALOX15 (1.00) | ALOX15ALDH1A1FFAR1SMN1; SMN2PTPN7 | |
| SCHEMBL1318870 | 0.79 | ALOX15 (1.00) | ALOX15ALDH1A1FFAR1SMN1; SMN2PTPN7 | |
| SCHEMBL826073 | 0.79 | L3MBTL1 (0.61) | FFAR1TSHRLMNAMCL1 | |
| SCHEMBL7248108 | 0.79 | MAPT (0.59) | ALOX15ALDH1A1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 559 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190031618-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-31 | — | — | US | claimed |
| US-10118900-B2 | Benzimidazole derivatives useful as CB-1 inverse agonists | JANSSEN PHARMACEUTICA NV (BE) | 2018-11-06 | — | — | US | claimed |
| US-9682955-B2 | Quinazoline derivatives useful as CB-1 inverse agonists | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-20 | — | — | US | claimed |
| US-9682940-B2 | Indazole derivatives useful as CB-1 inverse agonists | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-20 | — | — | US | claimed |
| US-20170057929-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | US | claimed |
| US-20170057925-A1 | INDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | US | claimed |
| WO-2017034872-A1 | INDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | claimed |
| WO-2017035114-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | claimed |
| EP-2318006-B1 | NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS | NIVALIS THERAPEUTICS INC (US) | 2016-10-12 | — | — | EP | claimed |
| WO-2016040081-A1 | QUINAZOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-17 | — | — | WO | claimed |
| EP-0654995-B1 | 4-OXA-1-AZABICYCLO (3,2,0) HEPTAN-7-ONE DERIVATIVES AS ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO LTD (JP) | 1996-10-23 | — | — | EP | claimed |
| US-5561126-A | OXAPENAMS HAVING CHEMICAL STABILITY; ANTICARCINOGENIC AGENTS; LEUKEMIA | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 1996-10-01 | — | — | US | claimed |
| US-5534395-A | Method of processing silver halide color photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1996-07-09 | — | — | US | claimed |
| EP-0654995-A1 | 4-OXA-1-AZABICYCLO (3,2,0) HEPTAN-7-ONE DERIVATIVES AS ANTITUMOR AGENTS. | TAIHO PHARMACEUTICAL CO LTD (JP) | 1995-05-31 | — | — | EP | claimed |
| CN-1082548-A | Antineoplastic agent 4-oxa--1-azabicyclo [3,2, O] heptane-7-ketone derivatives | MEDICINE BIOLOG TECH I CHINA M (CN) | 1994-02-23 | — | — | CN | claimed |
| WO-1994001109-A1 | 4-OXA-1-AZABICYCLO [3,2,0] HEPTAN-7-ONE DERIVATIVES AS ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO. LTD. (JP) | 1994-01-20 | — | — | WO | claimed |
| EP-0320776-B1 | COLOR PHOTOGRAPHIC SILVER HALIDE MATERIAL | Agfa-Gevaert AG (DE) | 1993-03-31 | — | — | EP | claimed |
| US-4898811-A | STABILITY | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | claimed |
| US-4091213-A | 7-Cyclizedamino-3-heterothiomethyl cephalosporin derivatives | BRISTOL-MYERS COMPANY (US) | 1978-05-23 | — | — | US | claimed |
| US-4026888-A | ANTIBIOTICS, BACTERICIDES | BRISTOL-MYERS COMPANY (US) | 1977-05-31 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031618-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | CNR1, GPR119, CNR2 | ALOX15 2068/4885ALDH1A1 528/4885FFAR1 15/4885 |
| US-20170057929-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | CNR1, GPR119, CNR2 | ALOX15 2088/4885ALDH1A1 517/4885FFAR1 16/4885 |
| US-10118900-B2 | Benzimidazole derivatives useful as CB-1 inverse agonists | CNR1, GPR119, CNR2 | ALOX15 2088/4885ALDH1A1 517/4885FFAR1 16/4885 |
| US-20170057925-A1 | INDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | CNR1, GPR119, CNR2 | ALOX15 1393/4885ALDH1A1 689/4885FFAR1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.