Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCL5 | P13501 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19734482 | 1.00 | CCL5 (0.31) | CCL5CCR5SIGMAR1 | |
| SCHEMBL19731754 | 0.83 | HTR2A (0.37) | CCL5CCR5SIGMAR1 | |
| SCHEMBL19731725 | 0.83 | HTR2A (0.37) | CCL5CCR5SIGMAR1 | |
| SCHEMBL18249640 | 0.83 | CCL5 (0.36) | CCL5CCR5 | |
| SCHEMBL19734481 | 0.80 | ESR1 (0.30) | — | |
| SCHEMBL19734479 | 0.80 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL18249608 | 0.79 | CCL5 (0.33) | CCL5CCR5 | |
| SCHEMBL24362653 | 0.77 | SIGMAR1 (0.35) | SIGMAR1 | |
| SCHEMBL18249646 | 0.76 | SLC6A2 (0.33) | CCL5CCR5SIGMAR1 | |
| Oxalic Acid SCHEMBL18249620 | 0.76 | CCR5 (0.39) | CCL5CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216280-A1 | TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-12-21 | — | — | WO | disclosed |
| US-20170362228-A1 | TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362228-A1 | TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ESR2, GPER1, ESR1 | CCL5 3735/4885CCR5 2132/4885SIGMAR1 613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.