Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 3/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.80 |
| ▸ | POLB | P06746 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | STAT6 | P42226 | 1/20 | 0.60 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.60 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.60 |
| ▸ | HEXA | P06865 | 1/20 | 0.59 |
| ▸ | HEXB | P07686 | 1/20 | 0.59 |
| ▸ | TERT | O14746 | 2/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | AHR | P35869 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amonafide SCHEMBL6255345 | 0.89 | FTO (1.00) | FTOCYP2D6POLBMEN1KMT2A | |
| Amonafide SCHEMBL27226 | 0.89 | FTO (1.00) | FTOCYP2D6POLBMEN1KMT2A | |
| Amonafide SCHEMBL29352008 | 0.89 | FTO (1.00) | FTOCYP2D6POLBMEN1KMT2A | |
| Amonafide SCHEMBL1566668 | 0.88 | FTO (0.97) | FTOCYP2D6POLBMEN1KMT2A | |
| Amonafide SCHEMBL1051955 | 0.88 | FTO (0.97) | FTOCYP2D6POLBMEN1KMT2A | |
| Amonafide SCHEMBL1049714 | 0.88 | FTO (0.97) | FTOCYP2D6POLBMEN1KMT2A | |
| SCHEMBL9017071 | 0.87 | FTO (0.71) | FTOCYP2D6POLBMEN1KMT2A | |
| Amonafide SCHEMBL20242315 | 0.84 | FTO (0.88) | FTOCYP2D6POLBMEN1KMT2A | |
| Amonafide SCHEMBL1565520 | 0.83 | FTO (0.86) | FTOCYP2D6POLBMEN1KMT2A | |
| Amonafide SCHEMBL9144516 | 0.83 | FTO (0.86) | FTOCYP2D6POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11007271-B2 | Anticancer drug conjugates | Ariel Scientific Innovations Ltd. (IL) | 2021-05-18 | — | — | US | disclosed |
| US-20190224328-A1 | ANTICANCER DRUG CONJUGATES | Ariel Scientific Innovations Ltd. (IL) | 2019-07-25 | — | — | US | disclosed |
| WO-2017216791-A9 | ANTICANCER DRUG CONJUGATES | Ariel Scientific Innovations Ltd. (IL) | 2018-02-08 | — | — | WO | disclosed |
| WO-2017216791-A1 | ANTICANCER DRUG CONJUGATES | Ariel Scientific Innovations Ltd. (IL) | 2017-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190224328-A1 | ANTICANCER DRUG CONJUGATES | BCR, MCL1, TP53 | FTO 3650/4885CYP2D6 1582/4885POLB 3284/4885 |
| US-11007271-B2 | Anticancer drug conjugates | BCR, MCL1, TP53 | FTO 3650/4885CYP2D6 1582/4885POLB 3284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.