Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | MDH2 | P40926 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734436 | 0.75 | TAAR1 (0.49) | TAAR1ALOX15POLBHTR6MDM4 | |
| SCHEMBL2955878 | 0.72 | AADAT (0.42) | POLBHTR6MDH2HTR1AAADAT | |
| SCHEMBL14739742 | 0.68 | ALOX15 (0.41) | TAAR1ALOX15HTR1AFNTAFNTB | |
| SCHEMBL29868170 | 0.68 | ALDH1A1 (0.39) | ALOX15POLBALDH1A1TSHRCYP1A2 | |
| SCHEMBL662426 | 0.68 | ALDH1A1 (0.39) | ALOX15POLBALDH1A1TSHRCYP1A2 | |
| SCHEMBL2824824 | 0.68 | AADAT (0.41) | POLBHTR1AALDH1A1AADATCYP2C19 | |
| SCHEMBL10643092 | 0.67 | ALOX15 (0.49) | TAAR1ALOX15POLBHTR6HTR1A | |
| SCHEMBL24855130 | 0.66 | BRD4 (0.41) | TSHR | |
| SCHEMBL29584855 | 0.66 | ALDH1A1 (0.54) | TAAR1ALOX15HTR1AALDH1A1TSHR | |
| SCHEMBL24424429 | 0.66 | ALDH1A1 (0.54) | TAAR1ALOX15HTR1AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3260118-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2017-12-27 | — | — | EP | disclosed |