Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 6/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.43 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARD | Q03181 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL19732971 | 1.00 | LMNA (0.48) | LMNASLC22A6TP53TSHRNFKB1 | |
| Adipic Acid SCHEMBL5306019 | 0.89 | LMNA (0.61) | LMNASLC22A6TP53TSHRNFKB1 | |
| Glutarate SCHEMBL28852051 | 0.89 | SLC22A6 (0.61) | LMNASLC22A6TP53TSHRNFKB1 | |
| Succinic Acid SCHEMBL935212 | 0.83 | TP53 (0.69) | LMNASLC22A6TP53OR51E2 | |
| Succinic Acid SCHEMBL15949792 | 0.83 | TP53 (0.69) | LMNASLC22A6TP53OR51E2 | |
| Malonic Acid SCHEMBL5996614 | 0.83 | TP53 (0.69) | LMNASLC22A6TP53ALDH1A1TDP1 | |
| Adipic Acid SCHEMBL28082470 | 0.83 | LMNA (0.69) | LMNASLC22A6TSHRNFKB1PMP22 | |
| Succinic Acid SCHEMBL8157901 | 0.81 | TP53 (0.65) | LMNASLC22A6TP53OR51E2 | |
| Succinic Acid SCHEMBL8148316 | 0.81 | TP53 (0.65) | LMNASLC22A6TP53OR51E2 | |
| Succinic Acid SCHEMBL4366411 | 0.81 | TP53 (0.65) | LMNASLC22A6TP53OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994305-B1 | HYDROPHILIC MICROFIBERS AND NANOFIBERS IN COATING COMPOSITIONS | EMPIRE TECHNOLOGY DEV LLC (US) | 2017-12-27 | — | — | EP | disclosed |