SCHEMBL19734470

SCHEMBL19734470

CCCCCc1[nH]c2ccccc2c1CC(C)C

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.54
CHRNA7 P36544 2/20 0.54
CHRNA4 P43681 2/20 0.54
KDM4E B2RXH2 5/20 0.48
ALDH1A1 P00352 4/20 0.48
HPGD P15428 4/20 0.48
HSD17B10 Q99714 4/20 0.48
GAA P10253 1/20 0.48
OXER1 Q8TDS5 1/20 0.47
CTSV O60911 2/20 0.46
CTSL P07711 2/20 0.46
CYP1A2 P05177 3/20 0.44
CYP3A4 P08684 2/20 0.44
TSHR P16473 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2C19 P33261 2/20 0.44
MAPT P10636 1/20 0.44
ALOX15 P16050 1/20 0.44
MTNR1A P48039 1/20 0.44
MTNR1B P49286 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19734471 0.95 CHRNB2 (0.55) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1
SCHEMBL5409935 0.89 CHRNB2 (0.60) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1
SCHEMBL31091563 0.88 CHRNB2 (0.59) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1
SCHEMBL28674730 0.88 CHRNB2 (0.59) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1
SCHEMBL7089878 0.84 CHRNB2 (0.55) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1
SCHEMBL27361702 0.83 CHRNB2 (0.49) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1
SCHEMBL5456514 0.82 ALDH1A1 (0.54) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1
SCHEMBL11415261 0.81 KDM4E (0.56) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1
SCHEMBL28987798 0.81 CHRNB2 (0.58) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1
SCHEMBL29072448 0.79 OXER1 (0.54) CHRNB2CHRNA7CHRNA4KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3472162-B1 HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF HOFFMANN LA ROCHE (CH) 2021-11-17 EP disclosed
WO-2017216280-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2017-12-21 WO disclosed