Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19735065 | 0.79 | CHRM3 (0.43) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL19734865 | 0.74 | MEN1 (0.40) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL19716496 | 0.74 | NSD2 (0.44) | KDM4EPKMALDH1A1MEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL19717539 | 0.72 | MEN1 (0.39) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL25394224 | 0.71 | PDE10A (0.55) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL21048241 | 0.71 | PKM (0.38) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL9909077 | 0.71 | ALDH1A1 (0.46) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL19717322 | 0.69 | MAPK1 (0.37) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL17225065 | 0.69 | KDM4E (0.37) | KDM4EPKMALDH1A1MEN1KMT2A | |
| SCHEMBL17236143 | 0.69 | KDM4E (0.41) | KDM4EPKMALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216726-A1 | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-12-21 | — | — | WO | disclosed |
| WO-2017216727-A1 | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-12-21 | — | — | WO | disclosed |