Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10618424 | 0.74 | HPGD (0.52) | LMNAL3MBTL1KDM4ETRPA1ATM | |
| SCHEMBL16488395 | 0.74 | LMNA (0.45) | LMNAALDH1A1KDM4E | |
| SCHEMBL27575979 | 0.74 | LMNA (0.45) | LMNAALDH1A1KDM4ETRPA1ATM | |
| SCHEMBL1950755 | 0.72 | LMNA (0.43) | LMNAALDH1A1TRPA1ATMHPGD | |
| SCHEMBL4740644 | 0.71 | SRC (0.50) | LMNAPKMSMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL21687922 | 0.71 | SRC (0.50) | LMNAPKMSMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL21687919 | 0.71 | SRC (0.50) | LMNAPKMSMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL9755853 | 0.71 | NPC1 (0.42) | LMNAPKMSMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL8203867 | 0.70 | SMN1; SMN2 (0.44) | LMNAPKMSMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL9756551 | 0.68 | NPC1 (0.47) | LMNAPKMSMN1; SMN2L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216280-A1 | TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-12-21 | — | — | WO | disclosed |