Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.52 |
| ▸ | HPGD | P15428 | 9/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19717348 | 0.89 | KDM4E (0.43) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL19734698 | 0.87 | KDM4E (0.54) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL19717166 | 0.87 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL29658484 | 0.87 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL19734994 | 0.85 | DNMT1 (0.53) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL19717563 | 0.83 | KDM4E (0.47) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL19734950 | 0.83 | DNMT1 (0.40) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL28737334 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL19734861 | 0.80 | KDM4E (0.49) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL19734688 | 0.79 | KDM4E (0.43) | ALDH1A1KDM4EHPGDGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216726-A1 | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-12-21 | — | — | WO | disclosed |
| WO-2017216727-A1 | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-12-21 | — | — | WO | disclosed |