Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 9/20 | 0.50 |
| ▸ | KHK | P50053 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19734832 | 0.87 | ALDH1A1 (0.52) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL19734567 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1POLBHPGDKHK | |
| SCHEMBL29658476 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1POLBHPGDKHK | |
| SCHEMBL19717161 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1POLBHPGDKHK | |
| SCHEMBL19734994 | 0.81 | DNMT1 (0.53) | KDM4EALDH1A1POLBHPGDMEN1 | |
| SCHEMBL19717348 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL19734950 | 0.79 | DNMT1 (0.40) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL19717563 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL19734683 | 0.79 | KDM4E (0.36) | KDM4EALDH1A1POLBHPGDKHK | |
| SCHEMBL29658663 | 0.79 | KDM4E (0.36) | KDM4EALDH1A1POLBHPGDKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017216727-A1 | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-12-21 | — | — | WO | disclosed |
| WO-2017216726-A1 | SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-12-21 | — | — | WO | disclosed |