Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.41 |
| ▸ | HPGD | P15428 | 7/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19717166 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDGAADNMT1 | |
| SCHEMBL19734832 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL19717353 | 0.85 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDGAADNMT1 | |
| SCHEMBL29658627 | 0.85 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDGAADNMT1 | |
| SCHEMBL19734994 | 0.84 | DNMT1 (0.53) | ALDH1A1KDM4EHPGDGAADNMT1 | |
| SCHEMBL19734950 | 0.81 | DNMT1 (0.40) | ALDH1A1KDM4EHPGDGAADNMT1 | |
| SCHEMBL19717302 | 0.80 | DNMT1 (0.38) | ALDH1A1KDM4EHPGDGAADNMT1 | |
| SCHEMBL29658560 | 0.80 | DNMT1 (0.38) | ALDH1A1KDM4EHPGDGAADNMT1 | |
| SCHEMBL19734861 | 0.79 | KDM4E (0.49) | ALDH1A1KDM4EHPGDGAADNMT1 | |
| SCHEMBL19734698 | 0.78 | KDM4E (0.54) | ALDH1A1KDM4EHPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563043-B | Substituted pyridines as inhibitors of DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2022-05-31 | — | — | CN | disclosed |