Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826388 | 0.83 | CSNK1A1 (0.41) | CSNK1A1CLK4KMT2ATSHRALDH1A1 | |
| SCHEMBL29741000 | 0.80 | TSHR (0.39) | CSNK1A1CLK4KMT2ATSHRALDH1A1 | |
| SCHEMBL19009020 | 0.80 | TSHR (0.39) | CSNK1A1CLK4KMT2ATSHRALDH1A1 | |
| SCHEMBL2981053 | 0.80 | CSNK1A1 (0.39) | CSNK1A1CLK4KMT2ATSHRHTT | |
| SCHEMBL26194109 | 0.77 | TSHR (0.37) | CSNK1A1CLK4KMT2ATSHRHTT | |
| SCHEMBL1145552 | 0.76 | CSNK1A1 (0.39) | CSNK1A1CLK4KMT2AALDH1A1NPSR1 | |
| SCHEMBL1145686 | 0.76 | CSNK1A1 (0.39) | CSNK1A1CLK4KMT2AALDH1A1NPSR1 | |
| SCHEMBL22890442 | 0.76 | LRRK2 (0.36) | CSNK1A1CLK4KMT2AALDH1A1NPSR1 | |
| SCHEMBL20302398 | 0.75 | CSNK1A1 (0.41) | CSNK1A1CLK4KMT2AALDH1A1NPSR1 | |
| SCHEMBL18299745 | 0.75 | TSHR (0.35) | CSNK1A1CLK4KMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3421456-A1 | NEW ROUTE OF SYNTHESIS FOR OPICAPONE | AZAD Pharmaceutical Ingredients AG (CH) | 2019-01-02 | — | — | EP | claimed |
| US-20180370958-A1 | Route Of Synthesis For Opicapone | AZAD PHARMACEUTICAL INGREDIENTS AG (CH) | 2018-12-27 | — | — | US | claimed |
| US-20230348490-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2023-11-02 | — | — | US | disclosed |
| EP-4186910-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2023-05-31 | — | — | EP | disclosed |
| CN-116178391-A | Forward allosteric modulators of muscarinic acetylcholine receptor M4 | 范德比尔特大学 | 2023-05-30 | — | — | CN | disclosed |
| CN-109310668-B | Positive allosteric modulators of muscarinic acetylcholine receptor M4 | 范德比尔特大学 | 2023-01-24 | — | — | CN | disclosed |
| US-20230014109-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2023-01-19 | — | — | US | disclosed |
| US-11142532-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2021-10-12 | — | — | US | disclosed |
| WO-2021007477-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2021-01-14 | — | — | WO | disclosed |
| US-20190161498-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-05-30 | — | — | US | disclosed |
| EP-3474846-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2019-05-01 | — | — | EP | disclosed |
| US-10239887-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2019-03-26 | — | — | US | disclosed |
| EP-3421456-A1 | NEW ROUTE OF SYNTHESIS FOR OPICAPONE | AZAD Pharmaceutical Ingredients AG (CH) | 2019-01-02 | — | — | EP | disclosed |
| US-20180370958-A1 | Route Of Synthesis For Opicapone | AZAD PHARMACEUTICAL INGREDIENTS AG (CH) | 2018-12-27 | — | — | US | disclosed |
| US-20170369505-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2017-12-28 | — | — | US | disclosed |
| WO-2017223290-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2017-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014109-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | CSNK1A1 1735/4885CLK4 2969/4885KMT2A 855/4885 |
| US-20230348490-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | CSNK1A1 1735/4885CLK4 2969/4885KMT2A 855/4885 |
| US-11142532-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM5, CHRM2 | CSNK1A1 1735/4885CLK4 2969/4885KMT2A 855/4885 |
| US-20190161498-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | CSNK1A1 1735/4885CLK4 2969/4885KMT2A 855/4885 |
| US-20170369505-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | CSNK1A1 1735/4885CLK4 2969/4885KMT2A 855/4885 |
| US-20180370958-A1 | Route Of Synthesis For Opicapone | OPRM1, OPRK1, OPRD1 | CSNK1A1 2139/4885CLK4 1061/4885KMT2A 1766/4885 |
| US-10239887-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM5, CHRM2 | CSNK1A1 1735/4885CLK4 2969/4885KMT2A 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.