Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25241698 | 0.72 | GRM4 (0.34) | MAP4K4CSNK1A1CDK5CLK4CYP1A2 | |
| SCHEMBL25239396 | 0.72 | — | — | |
| SCHEMBL28494856 | 0.72 | ADORA2A (0.52) | LMNAADORA3ADORA1ADORA2AKDM4E | |
| SCHEMBL439446 | 0.70 | KDM4E (0.43) | LMNAADORA1ADORA2AAURKBKDM4E | |
| SCHEMBL31046570 | 0.70 | KDM4E (0.43) | LMNAADORA1ADORA2AAURKBKDM4E | |
| SCHEMBL31347131 | 0.69 | — | — | |
| SCHEMBL19743476 | 0.69 | METAP2 (0.45) | LMNAADORA3ADORA1ADORA2AFGFR1 | |
| SCHEMBL13360778 | 0.66 | ADORA1 (0.50) | LMNAADORA1ADORA2AKDM4EHPGD | |
| SCHEMBL30866395 | 0.65 | KDM4E (0.50) | LMNAADORA1ADORA2AAURKBKDM4E | |
| SCHEMBL440401 | 0.65 | KDM4E (0.41) | LMNAADORA1ADORA2AAURKBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017220431-A1 | FUSED PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2017-12-28 | — | — | WO | disclosed |