Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 11/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA9 | Q16790 | 4/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29503477 | 1.00 | PTGS2 (0.50) | PTGS2CA2CA1CA9CA12 | |
| SCHEMBL28145710 | 0.85 | CA2 (0.49) | PTGS2CA2CA1CA9CA12 | |
| SCHEMBL1817484 | 0.81 | TRPV4 (0.47) | SMN1; SMN2GAAMAPK1KMT2ACYP1A1 | |
| SCHEMBL30540030 | 0.81 | TRPV4 (0.47) | SMN1; SMN2GAAMAPK1KMT2ACYP1A1 | |
| SCHEMBL27949851 | 0.81 | CYP1A1 (0.47) | CA2CA1CA9CA12SMN1; SMN2 | |
| SCHEMBL16936936 | 0.81 | CA2 (0.51) | PTGS2CA2CA1CA9CA12 | |
| SCHEMBL31235134 | 0.81 | CA2 (0.51) | PTGS2CA2CA1CA9CA12 | |
| SCHEMBL22492257 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2GAAMAPK1KMT2ACYP1A1 | |
| SCHEMBL24010102 | 0.80 | SMN1; SMN2 (0.47) | PTGS2SMN1; SMN2GAAMAPK1KMT2A | |
| Hydrochloric Acid SCHEMBL28128745 | 0.80 | CYP1A1 (0.46) | CA2CA1CA9CA12SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311894-A | N- (substituted-phenyl) -sulfonamide derivatives as kinase inhibitors | 内尔维阿诺医学科学有限公司 | 2019-02-05 | — | — | CN | claimed |
| EP-3472165-A1 | N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2019-04-24 | — | — | EP | disclosed |
| CN-109311894-A | N- (substituted-phenyl) -sulfonamide derivatives as kinase inhibitors | 内尔维阿诺医学科学有限公司 | 2019-02-05 | — | — | CN | disclosed |
| WO-2017220477-A1 | N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-12-28 | — | — | WO | disclosed |