Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | HTRA1 | Q92743 | 12/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19745089 | 1.00 | CTSS (0.50) | CTSSCTSKHTRA1AGTR2ACE | |
| SCHEMBL21119405 | 0.91 | CTSS (0.47) | CTSSCTSKHTRA1AGTR2 | |
| SCHEMBL21488665 | 0.86 | CTSS (0.53) | CTSSCTSKHTRA1ACEITGB3 | |
| SCHEMBL19747959 | 0.86 | CTSS (0.53) | CTSSCTSKHTRA1ACEITGB3 | |
| SCHEMBL19744673 | 0.83 | CTSS (0.56) | CTSSCTSKACE | |
| SCHEMBL19744672 | 0.83 | CTSS (0.56) | CTSSCTSKACE | |
| SCHEMBL19744561 | 0.81 | HTRA1 (0.58) | HTRA1 | |
| SCHEMBL19747491 | 0.81 | HTRA1 (0.58) | HTRA1 | |
| SCHEMBL28777990 | 0.81 | HTRA1 (0.58) | HTRA1 | |
| SCHEMBL19744562 | 0.81 | HTRA1 (0.58) | HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472130-B1 | ALIPHATIC PROLINAMIDE DERIVATIVES | Orion Ophthalmology LLC (US) | 2022-02-16 | — | — | EP | disclosed |
| US-11091465-B2 | — | — | 2021-08-17 | — | — | US | disclosed |
| US-20200385362-A1 | CARBOCYCLIC PROLINAMIDE DERIVATIVES | Orion Ophthalmology LLC (US) | 2020-12-10 | — | — | US | disclosed |
| US-10730832-B2 | Aliphatic prolinamide derivatives | Orion Ophthalmology LLC (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190330146-A1 | ALIPHATIC PROLINAMIDE DERIVATIVES | Orion Ophthalmology LLC (US) | 2019-10-31 | — | — | US | disclosed |
| EP-3472130-A1 | ALIPHATIC PROLINAMIDE DERIVATIVES | ORION OPTHALMOLOGY LLC (US) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017222917-A1 | ALIPHATIC PROLINAMIDE DERIVATIVES | INCEPTION 4, INC. (US) | 2017-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730832-B2 | Aliphatic prolinamide derivatives | HTRA1, ALDH1A2, PREP | CTSS 746/4885CTSK 1449/4885HTRA1 1/4885 |
| US-20200385362-A1 | CARBOCYCLIC PROLINAMIDE DERIVATIVES | HTRA1, ADCYAP1R1, HTRA2 | CTSS 402/4885CTSK 983/4885HTRA1 1/4885 |
| US-20190330146-A1 | ALIPHATIC PROLINAMIDE DERIVATIVES | HTRA1, ALDH1A2, PREP | CTSS 746/4885CTSK 1449/4885HTRA1 1/4885 |
| US-11091465-B2 | — | HTRA1, ALDH1A2, ADCYAP1R1 | CTSS 341/4885CTSK 823/4885HTRA1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.