Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | GFER | P55789 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889867 | 0.82 | ALDH1A1 (0.67) | ALDH1A1GFERMAPTKDM4EGAA | |
| SCHEMBL24013508 | 0.81 | ALDH1A1 (0.46) | ALDH1A1GFERMAPTKDM4EGAA | |
| SCHEMBL31276580 | 0.81 | KDM4E (0.68) | ALDH1A1GFERMAPTKDM4EGAA | |
| SCHEMBL17185444 | 0.79 | ALDH1A1 (0.44) | ALDH1A1GFERMAPTKDM4EGAA | |
| SCHEMBL2721634 | 0.78 | MAPT (0.53) | ALDH1A1GFERMAPTKDM4EGAA | |
| SCHEMBL15471933 | 0.77 | ALDH1A1 (0.68) | ALDH1A1GFERMAPTKDM4EGAA | |
| SCHEMBL15471931 | 0.77 | ALDH1A1 (0.44) | ALDH1A1GFERMAPTKDM4EGAA | |
| SCHEMBL15471934 | 0.77 | KDM4E (0.44) | ALDH1A1GFERMAPTKDM4EGAA | |
| SCHEMBL28754710 | 0.76 | HDAC3 (0.51) | ALDH1A1GFERMAPTKDM4EGAA | |
| SCHEMBL2293802 | 0.75 | MEN1 (0.60) | ALDH1A1GFERMAPTGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008507562-A | — | — | 2008-03-13 | — | — | JP | claimed |
| EP-1809332-A2 | COMPOSITIONS FOR MULTI-STEP DELIVERY OF HOT-SPOTS RADIATION TO CANCER CELLS | Oncologic, Inc. (US) | 2007-07-25 | — | — | EP | claimed |
| US-20060018908-A1 | Compositions and methods for treating cancer | ROSE, DAVID STUART | 2006-01-26 | — | — | US | claimed |
| WO-2006010165-A2 | COMPOSITIONS FOR MULTI-STEP DELIVERY OF HOT-SPOTS RADIATION TO CANCER CELLS | ONCOLOGIC, INC. (US) | 2006-01-26 | — | — | WO | claimed |
| EP-1809332-B1 | COMPOSITIONS FOR MULTI-STEP DELIVERY OF HOT-SPOTS RADIATION TO CANCER CELLS | ONCOLOGIC INC (US) | 2011-12-14 | — | — | EP | disclosed |
| US-20110142756-A1 | Method And Composition For The Treatment Of Cancer By The Enzymatic Conversion Of Soluble Radioactive Toxic Precipitates In The Cancer | Rose, David S. (US) | 2011-06-16 | — | — | US | disclosed |
| US-7807136-B2 | Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer | Rose, David S. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20100062006-A9 | Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer | MAYERS GEORGE L | 2010-03-11 | — | — | US | disclosed |
| US-7615221-B2 | Compositions and methods for treating cancer | ONCOLOGIC, INC. (US) | 2009-11-10 | — | — | US | disclosed |
| EP-1809332-A2 | COMPOSITIONS FOR MULTI-STEP DELIVERY OF HOT-SPOTS RADIATION TO CANCER CELLS | Oncologic, Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20060018908-A1 | Compositions and methods for treating cancer | ROSE, DAVID STUART | 2006-01-26 | — | — | US | disclosed |
| WO-2006010165-A2 | COMPOSITIONS FOR MULTI-STEP DELIVERY OF HOT-SPOTS RADIATION TO CANCER CELLS | ONCOLOGIC, INC. (US) | 2006-01-26 | — | — | WO | disclosed |
| US-20050058652-A1 | Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer | ROSE, DAVID STUART | 2005-03-17 | — | — | US | disclosed |