Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.56 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.56 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5478551 | 1.00 | CARM1 (0.56) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL8399769 | 0.89 | SIGMAR1 (0.57) | CARM1PRMT6PRMT8SIGMAR1MAOB | |
| SCHEMBL4798287 | 0.86 | CARM1 (0.53) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL14578374 | 0.85 | CARM1 (0.60) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL27376496 | 0.84 | TSHR (0.51) | CARM1PRMT6PRMT8TSHRALDH1A1 | |
| SCHEMBL16653971 | 0.83 | OPRK1 (0.45) | CARM1PRMT6PRMT8TSHRALDH1A1 | |
| SCHEMBL5482899 | 0.83 | CARM1 (0.50) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL9788223 | 0.83 | CARM1 (0.59) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL4802584 | 0.83 | CARM1 (0.50) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL4852041 | 0.82 | CARM1 (0.53) | CARM1PRMT6PRMT8SIGMAR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472148-A1 | CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2019-04-24 | — | — | EP | disclosed |
| WO-2017223016-A1 | CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-12-28 | — | — | WO | disclosed |