Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 4/20 | 0.40 |
| ▸ | GABRD | O14764 | 4/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.40 |
| ▸ | GABRE | P78334 | 4/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22042970 | 0.86 | PIK3CD (0.43) | MAPTKDM4EPIK3CDPIK3CBGABRP | |
| SCHEMBL5794092 | 0.82 | MAPT (0.46) | MAPTKDM4EPIK3CDPIK3CBGABRP | |
| SCHEMBL16067280 | 0.82 | MAPT (0.50) | MAPTKDM4EPIK3CDPIK3CBGABRP | |
| SCHEMBL6869457 | 0.81 | MAPT (0.46) | MAPTKDM4EPIK3CDPIK3CBGABRP | |
| SCHEMBL486127 | 0.80 | PIK3CG (0.58) | MAPTKDM4ENPC1RAB9ASOS1 | |
| SCHEMBL30358396 | 0.79 | MAPT (0.44) | MAPTKDM4EPIK3CDPIK3CBGABRP | |
| SCHEMBL23932508 | 0.79 | MAPT (0.46) | MAPTKDM4EDAGLANPC1RAB9A | |
| SCHEMBL4288555 | 0.79 | KDM4E (0.74) | MAPTKDM4EPIK3CDPIK3CBNPC1 | |
| SCHEMBL30041004 | 0.79 | MAPT (0.46) | MAPTKDM4EDAGLANPC1RAB9A | |
| SCHEMBL9199893 | 0.79 | ESR1 (0.53) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250163073-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2025-05-22 | — | — | US | disclosed |
| CN-119775261-A | Collagen 1 translation inhibitors and methods of use thereof | 艾尼莫生物科技公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-119775223-A | Benzoxazole derivative containing dithioacetal unit, and preparation method and application thereof | 贵州大学 | 2025-04-08 | — | — | CN | disclosed |
| CN-115427404-B | Collagen 1 translation inhibitors and methods of use thereof | 艾尼莫生物科技公司 | 2024-12-13 | — | — | CN | disclosed |
| US-12077547-B2 | Aldose reductase inhibitors and methods of use thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-09-03 | — | — | US | disclosed |
| CN-115160339-B | Aldose reductase inhibitors and methods of use thereof | 纽约市哥伦比亚大学理事会 | 2024-05-14 | — | — | CN | disclosed |
| EP-4316603-A2 | 4-OXO-3,4-DIHYDROTHIENO[3,4-D]PYRIDAZINE COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | The Trustees of Columbia University in the City of New York (US) | 2024-02-07 | — | — | EP | disclosed |
| EP-3757107-B1 | 4-OXO-3,4-DIHYDROTHIENO[3,4-D]PYRIDAZINE COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | UNIV COLUMBIA (US) | 2023-10-25 | — | — | EP | disclosed |
| US-20230312599-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2023-10-05 | — | — | US | disclosed |
| US-20230150980-A1 | COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF | ANIMA BIOTECH INC. (US) | 2023-05-18 | — | — | US | disclosed |
| EP-3757107-A1 | 4-OXO-3,4-DIHYDROTHIENO[3,4-D]PYRIDAZINE COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | The Trustees of Columbia University in the City of New York (US) | 2020-12-30 | — | — | EP | disclosed |
| US-10870658-B2 | Aldose reductase inhibitors and methods of use thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-12-22 | — | — | US | disclosed |
| US-20200283451-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2020-09-10 | — | — | US | disclosed |
| EP-3352754-B1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | UNIV COLUMBIA (US) | 2020-09-02 | — | — | EP | disclosed |
| US-10647726-B2 | Aldose reductase inhibitors and methods of use thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190300543-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-10-03 | — | — | US | disclosed |
| US-10150779-B2 | Aldose reductase inhibitors and methods of use thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-12-11 | — | — | US | disclosed |
| US-20180237451-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-08-23 | — | — | US | disclosed |
| EP-3352754-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | The Trustees of Columbia University in the City of New York (US) | 2018-08-01 | — | — | EP | disclosed |
| WO-2017223179-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250163073-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | ALDOA, AKR1B1, AKR1C2 | MAPT 1189/4885KDM4E 2144/4885PIK3CD 1826/4885 |
| US-10870658-B2 | Aldose reductase inhibitors and methods of use thereof | ALDOA, AKR1B1, AKR1C2 | MAPT 1189/4885KDM4E 2144/4885PIK3CD 1826/4885 |
| US-20230150980-A1 | COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF | COL1A1, COL2A1, COL14A1 | MAPT 3388/4885KDM4E 1980/4885PIK3CD 3553/4885 |
| US-20200283451-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | ALDOA, AKR1B1, AKR1C2 | MAPT 1189/4885KDM4E 2144/4885PIK3CD 1826/4885 |
| US-20180237451-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | ALDOA, AKR1B1, AKR1C2 | MAPT 1189/4885KDM4E 2144/4885PIK3CD 1826/4885 |
| US-20190300543-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | ALDOA, AKR1B1, AKR1C2 | MAPT 1189/4885KDM4E 2144/4885PIK3CD 1826/4885 |
| US-20230312599-A1 | ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF | ALDOA, AKR1B1, AKR1C2 | MAPT 1189/4885KDM4E 2144/4885PIK3CD 1826/4885 |
| US-10150779-B2 | Aldose reductase inhibitors and methods of use thereof | ALDOA, AKR1B1, AKR1C2 | MAPT 1189/4885KDM4E 2144/4885PIK3CD 1826/4885 |
| US-10647726-B2 | Aldose reductase inhibitors and methods of use thereof | ALDOA, AKR1B1, AKR1C2 | MAPT 1189/4885KDM4E 2144/4885PIK3CD 1826/4885 |
| US-12077547-B2 | Aldose reductase inhibitors and methods of use thereof | ALDOA, AKR1B1, AKR1C2 | MAPT 1189/4885KDM4E 2144/4885PIK3CD 1826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.