Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 16/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31717392 | 1.00 | PANK3 (0.50) | PANK3RIPK1SIGMAR1JAK2JAK1 | |
| SCHEMBL19748934 | 1.00 | PANK3 (0.50) | PANK3RIPK1SIGMAR1JAK2JAK1 | |
| SCHEMBL26501563 | 0.89 | GLS (0.41) | PANK3SIGMAR1 | |
| SCHEMBL23750436 | 0.85 | PANK3 (0.51) | PANK3RIPK1SIGMAR1JAK2JAK1 | |
| SCHEMBL21423669 | 0.85 | PANK3 (0.51) | PANK3RIPK1SIGMAR1 | |
| SCHEMBL31717785 | 0.85 | PANK3 (0.51) | PANK3RIPK1SIGMAR1 | |
| SCHEMBL24536009 | 0.85 | PANK3 (0.50) | PANK3RIPK1TACR3 | |
| SCHEMBL21406384 | 0.83 | PANK3 (0.52) | PANK3RIPK1JAK2JAK1JAK3 | |
| SCHEMBL31717786 | 0.83 | PANK3 (0.52) | PANK3RIPK1JAK2JAK1JAK3 | |
| SCHEMBL21406381 | 0.83 | PANK3 (0.52) | PANK3RIPK1JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12552765-B2 | Small molecule modulators of pantothenate kinases | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2026-02-17 | — | — | US | disclosed |
| US-20210246113-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2021-08-12 | — | — | US | disclosed |
| CN-109561680-B | Small molecule modulators of pantothenate kinase | 圣朱德儿童研究医院 | 2021-07-13 | — | — | CN | disclosed |
| US-20190300499-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2019-10-03 | — | — | US | disclosed |
| EP-3474667-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | St. Jude Children's Research Hospital, Inc. (US) | 2019-05-01 | — | — | EP | disclosed |
| WO-2017223474-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210246113-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | PANK2, PANK1, PANK3 | PANK3 3/4885RIPK1 87/4885SIGMAR1 4815/4885 |
| US-12552765-B2 | Small molecule modulators of pantothenate kinases | PANK3, PANK1, PANK2 | PANK3 1/4885RIPK1 171/4885SIGMAR1 3923/4885 |
| US-20190300499-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | PANK2, PANK1, PANK3 | PANK3 3/4885RIPK1 87/4885SIGMAR1 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.