Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | CNR2 | P34972 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.51 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646059 | 0.86 | ALDH1A1 (0.56) | CNR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL646058 | 0.86 | ALDH1A1 (0.56) | CNR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24130731 | 0.85 | ALDH1A1 (0.60) | HTTCNR2ALDH1A1NPC1LMNA | |
| SCHEMBL24130732 | 0.85 | ALDH1A1 (0.60) | HTTCNR2ALDH1A1NPC1LMNA | |
| SCHEMBL25260132 | 0.80 | ALDH1A1 (0.46) | HTTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3315713 | 0.80 | ALDH1A1 (0.46) | HTTALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3343332 | 0.79 | PSEN1 (0.43) | HTTTDP1 | |
| SCHEMBL24130359 | 0.77 | ALDH1A1 (0.60) | HTTCNR2ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6403555 | 0.77 | HTT (0.58) | HTTCNR2ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL24130360 | 0.77 | ALDH1A1 (0.60) | HTTCNR2ALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232302-B2 | Thiazoles and oxazoles useful as modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-31 | — | — | US | disclosed |
| US-20110144123-A1 | Thiazoles and Oxazoles Useful as Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-16 | — | — | US | disclosed |
| US-7846951-B2 | Thiazoles and oxazoles useful as modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-07 | — | — | US | disclosed |
| EP-2140865-A1 | Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters | Vertex Pharmaceuticals Incorporated (US) | 2010-01-06 | — | — | EP | disclosed |
| EP-1682127-B1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20090018140-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-01-15 | — | — | US | disclosed |
| US-7407976-B2 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-05 | — | — | US | disclosed |
| EP-1682127-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050130970-A1 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-16 | — | — | US | disclosed |
| WO-2005049018-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018140-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | HTT 2297/4885CNR2 2817/4885ALDH1A1 1101/4885 |
| US-20050130970-A1 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters | CFTR, ABCB1, ABCC2 | HTT 2297/4885CNR2 2817/4885ALDH1A1 1101/4885 |
| US-20110144123-A1 | Thiazoles and Oxazoles Useful as Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | HTT 2297/4885CNR2 2817/4885ALDH1A1 1101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.