Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646058 | 1.00 | ALDH1A1 (0.56) | ALDH1A1CYP2C9THRBCYP2C19HSD17B10 | |
| SCHEMBL7097974 | 0.88 | POLB (0.52) | ALDH1A1CYP2C9THRBCYP2C19HSD17B10 | |
| SCHEMBL4156603 | 0.88 | ATM (0.65) | ALDH1A1CYP2C9THRBCYP2C19HSD17B10 | |
| SCHEMBL4156601 | 0.88 | ATM (0.65) | ALDH1A1CYP2C9THRBCYP2C19HSD17B10 | |
| SCHEMBL1974909 | 0.86 | HTT (0.61) | ALDH1A1CNR2LMNASMN1; SMN2 | |
| SCHEMBL10660589 | 0.86 | ALDH1A1 (0.51) | ALDH1A1CNR2L3MBTL1POLBCTSL | |
| SCHEMBL646257 | 0.86 | CNR2 (0.54) | ALDH1A1CNR2L3MBTL1POLBCTSL | |
| SCHEMBL7453658 | 0.86 | CNR2 (0.54) | ALDH1A1CNR2L3MBTL1POLBCTSL | |
| SCHEMBL644992 | 0.86 | CNR2 (0.54) | ALDH1A1CNR2L3MBTL1POLBCTSL | |
| SCHEMBL2324112 | 0.86 | CNR2 (0.54) | ALDH1A1CNR2L3MBTL1POLBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119375-B2 | Method for the production of ramipril | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| EP-1966118-B1 | IMPROVED METHOD FOR THE PRODUCTION OF RAMIPRIL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-03-11 | — | — | EP | disclosed |
| US-20090017509-A1 | METHOD FOR THE PRODUCTION OF RAMIPRIL | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-01-15 | — | — | US | disclosed |
| EP-1966118-A1 | IMPROVED METHOD FOR THE PRODUCTION OF RAMIPRIL | Sanofi-Aventis Deutschland GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079871-A1 | IMPROVED METHOD FOR THE PRODUCTION OF RAMIPRIL | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |
| EP-0123442-B1 | IMPROVEMENTS IN OR RELATING TO A PROCESS FOR PRODUCING BETA-LACTAM COMPOUNDS | THE UNIVERSITY OF NOTRE DAME DU LAC (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4675399-A | N-HYDROXY-2-AZETIDINONES; ACYLATION, SOLVOLYSIS | NOTRE DAME UNIVERSITY (US) | 1987-06-23 | — | — | US | disclosed |
| US-4565654-A | BETA-LACTAMASE ENZYME INHIBITORS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 1986-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090017509-A1 | METHOD FOR THE PRODUCTION OF RAMIPRIL | REN, PDE8B, PDE3A | ALDH1A1 460/4885CYP2C9 140/4885THRB 3196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.