Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.56 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL554787 | 0.87 | KLKB1 (0.54) | KLKB1SAE1UBA2HDAC1HDAC8 | |
| SCHEMBL11910637 | 0.86 | DAGLA (0.55) | KLKB1LMNAGAAPOLBSLC6A2 | |
| SCHEMBL15001329 | 0.76 | SLC6A2 (0.45) | KLKB1GSK3BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2116168 | 0.76 | DAGLA (0.43) | GSK3BSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL16130104 | 0.76 | DAGLA (0.43) | SLC6A2SLC6A4SLC6A3CACNA1GDAGLA | |
| SCHEMBL1706233 | 0.76 | LOXL2 (0.44) | KLKB1LMNAPOLBSLC6A2SLC6A4 | |
| SCHEMBL25002914 | 0.75 | HDAC1 (0.74) | HDAC1HDAC8HDAC6ALDH1A1CA1 | |
| SCHEMBL17562359 | 0.75 | SLC6A2 (0.42) | HDAC1HDAC8HDAC6GSK3BSLC6A2 | |
| SCHEMBL2172653 | 0.74 | DAGLA (0.42) | GSK3BSLC6A2SLC6A4SLC6A3CACNA1G | |
| SCHEMBL393999 | 0.74 | DAGLA (0.42) | GSK3BSLC6A2SLC6A4SLC6A3CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232302-B2 | Thiazoles and oxazoles useful as modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-31 | — | — | US | disclosed |
| US-20110144123-A1 | Thiazoles and Oxazoles Useful as Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-16 | — | — | US | disclosed |
| US-7846951-B2 | Thiazoles and oxazoles useful as modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-07 | — | — | US | disclosed |
| EP-2140865-A1 | Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters | Vertex Pharmaceuticals Incorporated (US) | 2010-01-06 | — | — | EP | disclosed |
| EP-1682127-B1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20090018140-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-01-15 | — | — | US | disclosed |
| US-7407976-B2 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-05 | — | — | US | disclosed |
| EP-1682127-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050130970-A1 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-16 | — | — | US | disclosed |
| WO-2005049018-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018140-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | KLKB1 3090/4885SAE1 4701/4885UBA2 3950/4885 |
| US-20050130970-A1 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters | CFTR, ABCB1, ABCC2 | KLKB1 3090/4885SAE1 4701/4885UBA2 3950/4885 |
| US-20110144123-A1 | Thiazoles and Oxazoles Useful as Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | KLKB1 3090/4885SAE1 4701/4885UBA2 3950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.