Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1975554 | 0.87 | KLKB1 (0.56) | KLKB1RAB9ANPC1SMN1; SMN2TDP1 | |
| SCHEMBL27912754 | 0.84 | ALDH1A1 (0.46) | KLKB1ALDH1A1HPGDMAPTGAA | |
| SCHEMBL11910638 | 0.82 | CES1 (0.50) | KLKB1TDP1ALDH1A1HPGDTSHR | |
| SCHEMBL17931593 | 0.81 | P4HTM (0.53) | LMNAHDAC6 | |
| SCHEMBL11910637 | 0.75 | DAGLA (0.55) | KLKB1ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL31604697 | 0.75 | HDAC1 (0.72) | ALDH1A1HPGDMAPTRECQLHDAC1 | |
| SCHEMBL3558466 | 0.73 | HCAR2 (0.45) | TDP1L3MBTL1LMNATSHRPOLB | |
| SCHEMBL21333174 | 0.73 | DAGLA (0.52) | KLKB1SMN1; SMN2MAPTLMNATSHR | |
| SCHEMBL15931718 | 0.72 | ALDH1A1 (0.58) | RAB9ANPC1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL11630361 | 0.72 | P4HTM (0.55) | RAB9ANPC1SMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9290485-B2 | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides | NOVARTIS AG (CH) | 2016-03-22 | — | — | US | disclosed |
| EP-2601189-B1 | N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES AS INHIBITORS OF PLASMA KALLIKREIN | NOVARTIS AG (CH) | 2015-04-15 | — | — | EP | disclosed |
| EP-2601189-A1 | N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES AS INHIBITORS OF PLASMA KALLIKREIN | Novartis AG (CH) | 2013-06-12 | — | — | EP | disclosed |
| US-8232302-B2 | Thiazoles and oxazoles useful as modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-31 | — | — | US | disclosed |
| US-20120035168-A1 | N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES | NOVARTIS AG (CH) | 2012-02-09 | — | — | US | disclosed |
| WO-2012017020-A1 | N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES AS INHIBITORS OF PLASMA KALLIKREIN | NOVARTIS AG (CH) | 2012-02-09 | — | — | WO | disclosed |
| US-20110144123-A1 | Thiazoles and Oxazoles Useful as Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-16 | — | — | US | disclosed |
| US-7846951-B2 | Thiazoles and oxazoles useful as modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-07 | — | — | US | disclosed |
| EP-2140865-A1 | Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters | Vertex Pharmaceuticals Incorporated (US) | 2010-01-06 | — | — | EP | disclosed |
| EP-1682127-B1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20090018140-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-01-15 | — | — | US | disclosed |
| US-7407976-B2 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-05 | — | — | US | disclosed |
| EP-1682127-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20050130970-A1 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-16 | — | — | US | disclosed |
| WO-2005049018-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018140-A1 | THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | KLKB1 3090/4885RAB9A 3491/4885NPC1 64/4885 |
| US-20050130970-A1 | Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters | CFTR, ABCB1, ABCC2 | KLKB1 3090/4885RAB9A 3491/4885NPC1 64/4885 |
| US-20120035168-A1 | N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES | TPMT, REN, PNMT | KLKB1 4526/4885RAB9A 4147/4885NPC1 1473/4885 |
| US-20110144123-A1 | Thiazoles and Oxazoles Useful as Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | KLKB1 3090/4885RAB9A 3491/4885NPC1 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.