⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19078924 | 1.00 | — | — | |
| SCHEMBL12416160 | 1.00 | — | — | |
| SCHEMBL19051013 | 1.00 | — | — | |
| SCHEMBL19078920 | 0.86 | SSTR1 (0.34) | — | |
| SCHEMBL19760422 | 0.86 | SSTR1 (0.34) | — | |
| SCHEMBL10366417 | 0.85 | FGF1 (0.31) | — | |
| SCHEMBL18294595 | 0.85 | FGF1 (0.33) | — | |
| SCHEMBL19051014 | 0.85 | FGF1 (0.33) | — | |
| SCHEMBL25605193 | 0.85 | FGF1 (0.33) | — | |
| SCHEMBL25594520 | 0.85 | FGF1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240026360-A1 | OLIGONUCLEOTIDES FOR MODULATING TAU EXPRESSION | HOFFMANN LA ROCHE (US) | 2024-01-25 | — | — | US | disclosed |
| US-20230257748-A1 | USE OF A1CF INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2023-08-17 | — | — | US | disclosed |
| US-20230174982-A1 | ENGINEERED NUCLEIC ACIDS AND USES THEREOF | THE METHODIST HOSPITAL SYSTEM | 2023-06-08 | — | — | US | disclosed |
| US-11667660-B2 | Pyridinium salts as activators in the synthesis of stereodefined oligonucleotides | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2023-06-06 | — | — | US | disclosed |
| US-20230132093-A1 | EXTRACELLULAR VESICLE-NLRP3 ANTAGONIST | CODIAK BIOSCIENCES, INC. (US) | 2023-04-27 | — | — | US | disclosed |
| US-20180002701-A1 | ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION | HOFFMANN-LA ROCHE INC. | 2018-01-04 | — | — | US | disclosed |