Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 10/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21377621 | 0.84 | CHEK1 (0.46) | JAK1CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL12920622 | 0.78 | CHEK1 (0.50) | JAK1CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL19762842 | 0.75 | JAK1 (0.75) | JAK1JAK2TYK2 | |
| Hydrochloric Acid SCHEMBL28842780 | 0.75 | RAB9A (0.44) | PDE10AMAPT | |
| SCHEMBL19762844 | 0.74 | CHEK1 (0.46) | JAK1CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL27675710 | 0.74 | CHEK1 (0.46) | JAK1CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL28842816 | 0.72 | JAK1 (0.41) | JAK1MAP4K4CSF1RPRKACAKDR | |
| SCHEMBL100904 | 0.71 | CHEK1 (0.46) | JAK1CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL103694 | 0.71 | NUDT1 (0.47) | JAK1CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL30827265 | 0.71 | TGFBR1 (0.35) | JAK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024511-B2 | Substituted imidazo[1,2-a]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof | SHANGHAI FUDAN-ZHANGJIANG BIO-PHARMACEUTICAL CO., LTD. (CN) | 2024-07-02 | — | — | US | disclosed |
| US-20180002328-A1 | SUBSTITUTED IMIDAZO[1, 2-A]PYRIDIN-2-YLAMINE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | JN THERAPEUTICS LTD. (CN) | 2018-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12024511-B2 | Substituted imidazo[1,2-a]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof | JAK1, JAK2, JAK3 | JAK1 1/4885CHEK1 615/4885MAP4K4 49/4885 |
| US-20180002328-A1 | SUBSTITUTED IMIDAZO[1, 2-A]PYRIDIN-2-YLAMINE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | JAK1, JAK2, JAK3 | JAK1 1/4885CHEK1 615/4885MAP4K4 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.