Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | EP300 | Q09472 | 2/20 | 0.52 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.52 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659312 | 0.83 | ALDH1A1 (0.62) | ALDH1A1HSD17B10CYP3A4TSHRHPGD | |
| SCHEMBL9232253 | 0.81 | LMNA (0.48) | ALDH1A1HSD17B10CYP3A4TSHRHPGD | |
| SCHEMBL10551961 | 0.79 | ALDH1A1 (0.50) | ALDH1A1HSD17B10CYP3A4TSHRHPGD | |
| SCHEMBL28942909 | 0.79 | HTT (0.52) | ALDH1A1HSD17B10IDO1PKMLMNA | |
| SCHEMBL30277950 | 0.79 | HTT (0.52) | ALDH1A1HSD17B10IDO1PKMLMNA | |
| SCHEMBL485855 | 0.78 | IDO1 (0.73) | ALDH1A1HSD17B10CYP3A4TSHRHPGD | |
| SCHEMBL8006509 | 0.78 | IDO1 (0.73) | ALDH1A1HSD17B10CYP3A4TSHRHPGD | |
| SCHEMBL8371459 | 0.78 | IDO1 (0.73) | ALDH1A1HSD17B10CYP3A4TSHRHPGD | |
| SCHEMBL29393764 | 0.78 | IDO1 (0.73) | ALDH1A1HSD17B10CYP3A4TSHRHPGD | |
| SCHEMBL29702452 | 0.78 | IDO1 (0.73) | ALDH1A1HSD17B10CYP3A4TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180000778-A1 | SMALL MOLECULE ANTAGONISTS OF DUSP5 AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180000778-A1 | SMALL MOLECULE ANTAGONISTS OF DUSP5 AND METHODS OF USE | DUSP5, DUSP15, DUSP2 | ALDH1A1 3103/4885HSD17B10 2434/4885CYP3A4 4874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.