Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.47 |
| ▸ | NPC1 | O15118 | 11/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21626683 | 0.89 | KCNH2 (0.50) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20625512 | 0.86 | KCNH2 (0.62) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21626682 | 0.86 | KCNH2 (0.50) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5429720 | 0.83 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19764151 | 0.80 | KCNH2 (0.56) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21626666 | 0.80 | MAPT (0.59) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19764161 | 0.79 | NOX1 (0.68) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20625511 | 0.78 | KCNH2 (0.58) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20625517 | 0.78 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21626837 | 0.78 | NPC1 (0.73) | RAB9ANPC1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200024224-A1 | ANTIFUNGAL COMPOUNDS AND METHODS OF FORMING THE SAME | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2020-01-23 | — | — | US | disclosed |
| US-10173968-B2 | Bishydrazone-based antifungal agents | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180009741-A1 | BISHYDRAZONE-BASED ANTIFUNGAL AGENTS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009741-A1 | BISHYDRAZONE-BASED ANTIFUNGAL AGENTS | DPM1, ERG28, SUCLG1 | RAB9A 3483/4885NPC1 928/4885SMN1; SMN2 4460/4885 |
| US-10173968-B2 | Bishydrazone-based antifungal agents | DPM1, ERG28, SUCLG1 | RAB9A 3483/4885NPC1 928/4885SMN1; SMN2 4460/4885 |
| US-20200024224-A1 | ANTIFUNGAL COMPOUNDS AND METHODS OF FORMING THE SAME | DPM1, ERG28, SUCLG1 | RAB9A 3696/4885NPC1 544/4885SMN1; SMN2 4136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.