Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.70 |
| ▸ | RAB9A | P51151 | 6/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | HPGD | P15428 | 4/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 3/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10632495 | 0.90 | MAPT (0.61) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL10635577 | 0.83 | KDM4E (0.59) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL16372919 | 0.80 | MAPT (0.61) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL11001442 | 0.80 | NPC1 (0.57) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL14758389 | 0.79 | PRKCE (0.60) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL19769225 | 0.79 | IKBKB (0.57) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL16451146 | 0.79 | MAPT (0.80) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL19769205 | 0.78 | MAPT (0.70) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL19769162 | 0.76 | SLC14A1 (0.81) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL16451143 | 0.76 | MAPT (0.74) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | CD4, CCR5, MMP8 | NPC1 27/4885RAB9A 2894/4885MAPT 1713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.