Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11578879 | 0.83 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTNPSR1KMT2A | |
| SCHEMBL1972236 | 0.83 | HSD17B10 (0.61) | ALDH1A1LMNAMAPTNPSR1KMT2A | |
| SCHEMBL10746533 | 0.81 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTNPSR1KMT2A | |
| SCHEMBL16707018 | 0.80 | ALDH1A1 (0.62) | ALDH1A1LMNAMAPTNPSR1KMT2A | |
| SCHEMBL5464054 | 0.79 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTNPSR1KMT2A | |
| SCHEMBL20614850 | 0.78 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTNPSR1KMT2A | |
| SCHEMBL17951303 | 0.77 | NPSR1 (0.55) | ALDH1A1LMNAMAPTNPSR1KMT2A | |
| SCHEMBL18791450 | 0.76 | CHEK1 (0.40) | ALDH1A1LMNAMAPTNPSR1KMT2A | |
| SCHEMBL5919129 | 0.76 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTNPSR1KMT2A | |
| SCHEMBL6643211 | 0.76 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015114663-A1 | NOVEL THIENO [2,3-D]PYRIMIDIN-4(3H)-ONE COMPOUNDS WITH ANTIMYCOBACTERIAL PROPERTIES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-08-06 | — | — | WO | disclosed |
| EP-2346861-B1 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-01-23 | — | — | EP | disclosed |
| US-8236840-B2 | Thiopene containing analogues of fluconazole as antifungal agents and process for their preparation | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-08-07 | — | — | US | disclosed |
| US-20110144171-A1 | THIOPENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS FOR THEIR PREPARATION | COUNCIL OF SCIENCE & INDUSTRIAL RESEARCH (IN) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144171-A1 | THIOPENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS FOR THEIR PREPARATION | CYP51A1, ERG28, TPMT | ALDH1A1 2097/4885LMNA 4704/4885MAPT 3756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.