Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1713357 | 0.78 | CACNA1B (0.39) | MAPTADRB2LOXL2 | |
| SCHEMBL12266204 | 0.76 | RXRA (0.34) | VNN1KDM4E | |
| SCHEMBL15821835 | 0.75 | MEN1 (0.32) | VNN1MAPT | |
| SCHEMBL297140 | 0.75 | KDM1A (0.50) | CYP3A4 | |
| SCHEMBL17501350 | 0.73 | MALT1 (0.39) | VNN1KDM4E | |
| SCHEMBL6346128 | 0.73 | KDM4E (0.41) | VNN1KDM4ECYP3A4MAPTADRB2 | |
| SCHEMBL469205 | 0.72 | NPC1 (0.37) | KDM4EMAPK1 | |
| SCHEMBL10115885 | 0.72 | ESR1 (0.35) | — | |
| SCHEMBL5659053 | 0.71 | LOXL2 (0.44) | VNN1ADRB2LOXL2 | |
| SCHEMBL1787959 | 0.71 | VNN1 (0.30) | VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411001-B1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME (US) | 2018-01-17 | — | — | EP | disclosed |