Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | GABRP | O00591 | 3/20 | 0.49 |
| ▸ | GABRD | O14764 | 3/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.49 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.49 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.49 |
| ▸ | GABRE | P78334 | 3/20 | 0.49 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.49 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.49 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.49 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19779949 | 0.81 | MTNR1A (0.49) | MTNR1AMTNR1BGABRPGABRDGABRA1 | |
| SCHEMBL19114399 | 0.78 | PIM1 (0.49) | MTNR1AMTNR1BPIM1PIM3PIM2 | |
| SCHEMBL7922832 | 0.77 | PIM1 (0.51) | PIM1PIM3PIM2DYRK1ATDO2 | |
| SCHEMBL30267619 | 0.77 | PRKAG1 (0.60) | MTNR1AMTNR1BGABRPGABRDGABRA1 | |
| SCHEMBL3033381 | 0.77 | ALDH1A1 (0.55) | MTNR1AMTNR1BGABRPGABRDGABRA1 | |
| SCHEMBL14041217 | 0.74 | PIM1 (0.49) | PIM1PIM3PIM2DYRK1ATDO2 | |
| SCHEMBL14041130 | 0.74 | PIM1 (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL25030233 | 0.72 | MTNR1A (0.71) | MTNR1AMTNR1BCHRNB2CHRNA4 | |
| SCHEMBL29612001 | 0.72 | HTR2A (0.59) | MTNR1AMTNR1BCYP2C9CYP2C19MAPT | |
| SCHEMBL25030236 | 0.72 | MTNR1A (0.60) | MTNR1AMTNR1BCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654867-B2 | Heteroaryl estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| WO-2018011628-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | LIFESCI PHARMACEUTICALS, INC. (BB) | 2018-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654867-B2 | Heteroaryl estrogen receptor modulators and uses thereof | ESR2, GPER1, ESRRA | MTNR1A 53/4885MTNR1B 70/4885GABRP 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.