Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | MAOB | P27338 | 8/20 | 0.45 |
| ▸ | GAA | P10253 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | GLA | P06280 | 5/20 | 0.45 |
| ▸ | CASP1 | P29466 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572672 | 0.81 | MAPT (0.51) | MAPTALDH1A1KDM4EMAOBGAA | |
| SCHEMBL1980452 | 0.75 | MAOB (0.43) | MAPTALDH1A1KDM4EMAOBGAA | |
| SCHEMBL1821389 | 0.74 | MAPT (0.71) | MAPTALDH1A1KDM4EMAOBGAA | |
| SCHEMBL16334610 | 0.73 | ALDH1A1 (0.53) | MAPTALDH1A1KDM4EMAOBGAA | |
| SCHEMBL9093546 | 0.73 | ALDH1A1 (0.53) | MAPTALDH1A1KDM4EMAOBGAA | |
| SCHEMBL12478166 | 0.72 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EMAOBGAA | |
| SCHEMBL2715253 | 0.72 | ALDH1A1 (0.44) | MAPTALDH1A1KDM4EMAOBGAA | |
| SCHEMBL12478248 | 0.72 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EMAOBGAA | |
| SCHEMBL31393622 | 0.72 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EMAOBGAA | |
| SCHEMBL6281474 | 0.72 | ALDH1A1 (0.59) | MAPTALDH1A1KDM4EMAOBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |