Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 11/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12478248 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTMAOBNPC1 | |
| SCHEMBL4727223 | 0.74 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPTMAOBNPC1 | |
| SCHEMBL12479215 | 0.73 | BRD4 (0.30) | — | |
| SCHEMBL1978049 | 0.72 | MAPT (0.51) | ALDH1A1KDM4EMAPTMAOBNPC1 | |
| SCHEMBL18572672 | 0.72 | MAPT (0.51) | ALDH1A1KDM4EMAPTMAOBNPC1 | |
| SCHEMBL10610370 | 0.71 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTMAOBNPC1 | |
| SCHEMBL7828336 | 0.71 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTMAOBNPC1 | |
| SCHEMBL4260350 | 0.71 | MAPT (0.67) | ALDH1A1KDM4EMAPTMAOBNPC1 | |
| SCHEMBL10403858 | 0.70 | ALDH1A1 (0.66) | ALDH1A1KDM4EMAPTMAOBNPC1 | |
| SCHEMBL6559398 | 0.70 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTMAOBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012110860-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-08-23 | — | — | WO | disclosed |
| WO-2012110860-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-08-23 | — | — | WO | disclosed |