Sugi Predict

Sugi Predict / Compounds / SCHEMBL1821389

SCHEMBL1821389

SCHEMBL1821389

CC1(C)CC(=O)c2cc(Br)ccc2O1

nearest known ligand 0.71

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 1/20 0.71
▸ KDM4E B2RXH2 12/20 0.58
▸ ALDH1A1 P00352 11/20 0.58
▸ GAA P10253 9/20 0.53
▸ HPGD P15428 6/20 0.53
▸ GLA P06280 5/20 0.53
▸ CASP1 P29466 2/20 0.53
▸ HSD17B10 Q99714 2/20 0.53
▸ CASP7 P55210 1/20 0.53
▸ MAOB P27338 3/20 0.53
▸ PBRM1 Q86U86 1/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.48
▸ NPC1 O15118 2/20 0.46
▸ HTT P42858 2/20 0.45
▸ LMNA P02545 1/20 0.45
▸ RAB9A P51151 1/20 0.45
▸ MALT1 Q9UDY8 1/20 0.43
▸ ATM Q13315 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6559273 0.88 MAPT (0.60) MAPTKDM4EALDH1A1GAAHPGD
SCHEMBL6552997 0.87 ALDH1A1 (0.67) MAPTKDM4EALDH1A1GAAHPGD
SCHEMBL29640611 0.87 ALDH1A1 (0.67) MAPTKDM4EALDH1A1GAAHPGD
SCHEMBL1146916 0.83 MAPT (1.00) MAPTKDM4EALDH1A1GAAHPGD
SCHEMBL68892 0.81 MAPT (0.69) MAPTKDM4EALDH1A1GAAHPGD
SCHEMBL2176991 0.80 KDM4E (0.49) MAPTKDM4EALDH1A1GAAHPGD
SCHEMBL4260350 0.80 MAPT (0.67) MAPTKDM4EALDH1A1GAAHPGD
SCHEMBL1979356 0.80 KDM4E (0.59) MAPTKDM4EPBRM1HTTATM
SCHEMBL11904084 0.80 MAPT (0.67) MAPTKDM4EALDH1A1GAAHPGD
SCHEMBL7957662 0.80 MAPT (0.67) MAPTKDM4EALDH1A1GAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250276962-A1 CONTRACEPTIVE COMPOUNDS AND METHODS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2025-09-04 — — US disclosed
US-12281105-B2 Contraceptive compounds and methods REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2025-04-22 — — US disclosed
EP-4371982-A2 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS RQX Pharmaceuticals, Inc. (US) 2024-05-22 — — EP disclosed
CN-117881674-A Contraceptive compounds and methods 明尼苏达大学董事会 2024-04-12 — — CN disclosed
US-20240109872-A1 CONTRACEPTIVE COMPOUNDS AND METHODS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2024-04-04 — — US disclosed
EP-3583096-B1 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS RQX PHARMACEUTICALS INC (US) 2024-03-27 — — EP disclosed
EP-4334309-A1 CONTRACEPTIVE COMPOUNDS AND METHODS Regents of the University of Minnesota (US) 2024-03-13 — — EP disclosed
US-11780828-B2 Contraceptive compounds and methods REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2023-10-10 — — US disclosed
US-11780828-B2 Contraceptive compounds and methods REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2023-10-10 — — US disclosed
US-11780828-B2 Contraceptive compounds and methods REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2023-10-10 — — US disclosed
WO-2000020370-A1 2, 4-PENTADIENOIC ACID DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X (RXR) RECEPTORS ALLERGAN SALES, INC. (US) 2000-04-13 — — WO disclosed
EP-0948478-A1 ARYL OR HETEROARYL SUBSTITUTED 3,4-DIHYDROANTHRACENE AND ARYL OR HETEROARYL SUBSTITUTED BENZO 1,2-g]-CHROM-3-ENE, BENZO 1,2-g]-THIOCHROM-3-ENE AND BENZO 1,2-g]-1,2-DIHYDROQUINOLINE DERIVATIVES HAVING RETINOID ANTAGONIST OR RETINOID INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY Allergan Sales, Inc. (US) 1999-10-13 — — EP disclosed
US-5958954-A 2,2-DIALKYL-4-ARYL-SUBSTITUTED BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES ALLERGAN SALES, INC. (US) 1999-09-28 — — US disclosed
WO-1999033821-A1 BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES HAVING RETINOID ANTAGONIST-LIKE ACTIVITY ALLERGAN SALES, INC. (US) 1999-07-08 — — WO disclosed
WO-1998025875-A1 ARYL OR HETEROARYL SUBSTITUTED 3,4-DIHYDROANTHRACENE AND ARYL OR HETEROARYL SUBSTITUTED BENZO[1,2-g]-CHROM-3-ENE, BENZO[1,2-g]-THIOCHROM-3-ENE AND BENZO[1,2-g]-1,2-DIHYDROQUINOLINE DERIVATIVES HAVING RETINOID ANTAGONIST OR RETINOID INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY ALLERGAN SALES, INC. (US) 1998-06-18 — — WO disclosed
US-5728846-A RETENOIDS, RETINOID ACTIVITY; AGONISTS, ANTAGONISTS ALLERGAN (US) 1998-03-17 — — US disclosed
US-5470872-A Benzopyranols BEECHAM GROUP PLC (GB) 1995-11-28 — — US disclosed
EP-0376524-B1 Benzopyran and related compounds BEECHAM GROUP PLC (GB) 1995-03-29 — — EP disclosed
EP-0633256-A1 Benzopyran and related compounds BEECHAM GROUP PLC (GB) 1995-01-11 — — EP disclosed
EP-0376524-A1 Benzopyran and related compounds BEECHAM GROUP PLC (GB) 1990-07-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250276962-A1 CONTRACEPTIVE COMPOUNDS AND METHODS CYP19A1, GNRHR, NR5A1 MAPT 4709/4885KDM4E 925/4885ALDH1A1 1128/4885
US-11780828-B2 Contraceptive compounds and methods CYP19A1, GNRHR, NR5A1 MAPT 4709/4885KDM4E 925/4885ALDH1A1 1128/4885
US-20240109872-A1 CONTRACEPTIVE COMPOUNDS AND METHODS CYP19A1, GNRHR, NR5A1 MAPT 4709/4885KDM4E 925/4885ALDH1A1 1128/4885
US-12281105-B2 Contraceptive compounds and methods CYP19A1, GNRHR, NR5A1 MAPT 4709/4885KDM4E 925/4885ALDH1A1 1128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.