Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28326646 | 0.88 | NAAA (0.37) | DAONAAA | |
| SCHEMBL28326636 | 0.86 | NAAA (0.42) | DAONAAA | |
| SCHEMBL456220 | 0.84 | — | — | |
| SCHEMBL1666337 | 0.80 | ADH1B (0.37) | — | |
| SCHEMBL1451000 | 0.80 | — | — | |
| SCHEMBL15304489 | 0.79 | DAO (0.30) | DAONAAA | |
| SCHEMBL28806594 | 0.79 | — | — | |
| SCHEMBL1861051 | 0.78 | MAOB (0.30) | — | |
| SCHEMBL5543967 | 0.78 | ADH1B (0.40) | — | |
| SCHEMBL27705383 | 0.78 | ADH1B (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115572252-A | Isoindolinone inhibitors of MDM2-P53 interaction with anti-cancer activity | 阿斯泰克斯治疗有限公司 | 2023-01-06 | — | — | CN | disclosed |
| CN-115368356-A | Bicyclic heterocyclic compounds and their therapeutic use | 阿斯特克斯治疗有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-108473464-B | Isoindolinone inhibitors of MDM2-P53 interaction with anti-cancer activity | 阿斯泰克斯治疗有限公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-108290871-B | Isoindolinone inhibitors of MDM2-P53 interaction with anti-cancer activity | 阿斯泰克斯治疗有限公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-109336883-B | Bicyclic heterocyclic compounds and their therapeutic use | 阿斯特克斯治疗有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-114206885-A | Pyrazolo [3,4-B ] pyrazine SHP2 phosphatase inhibitors | 大冢制药株式会社 | 2022-03-18 | — | — | CN | disclosed |
| CN-108137546-B | Bis-heteroaryl substituted 1, 4-benzodiazepine compounds and their use for the treatment of cancer | 詹森药业有限公司 | 2021-07-27 | — | — | CN | disclosed |
| CN-108026095-B | Novel compounds | 詹森药业有限公司 | 2021-07-27 | — | — | CN | disclosed |
| CN-111902415-A | Pharmaceutical compounds | 大冢制药株式会社 | 2020-11-06 | — | — | CN | disclosed |
| CN-106459010-B | Quinoxaline derivatives as FGFR kinase modulators | 阿斯特克斯治疗有限公司 | 2020-11-03 | — | — | CN | disclosed |
| EP-1416936-A1 | THIOPYRANE-4-ONES AS DNA PROTEIN KINASE INHIBITORS | Cancer Research Technology Limited (GB) | 2004-05-12 | — | — | EP | disclosed |
| EP-1397350-A1 | ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS | Kudos Pharmaceuticals Limited (GB) | 2004-03-17 | — | — | EP | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |
| WO-2003093261-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2003-11-13 | — | — | WO | disclosed |
| WO-2003070726-A1 | PYRANONES USEFUL AS ATM INHIBITORS | KUDOS PHARMACEUTICALS LTD (GB) | 2003-08-28 | — | — | WO | disclosed |
| EP-1330442-A1 | PHTHALAZINONE DERIVATIVES | Kudos Pharmaceuticals Limited (GB) | 2003-07-30 | — | — | EP | disclosed |
| WO-2003024949-A1 | DNA-PK INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-03-27 | — | — | WO | disclosed |
| WO-2003015790-A1 | THIOPYRANE-4-ONES AS DNA PROTEIN KINASE INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-02-27 | — | — | WO | disclosed |
| WO-2002090334-A1 | ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002036576-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2002-05-10 | — | — | WO | disclosed |