SCHEMBL19781206

SCHEMBL19781206

c1ccc2c(c1)Sc1ccc3c([nH]c4c5ccccc5ccc34)c1S2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.50
ALDH1A1 P00352 4/20 0.40
KDM4E B2RXH2 4/20 0.40
HPGD P15428 2/20 0.40
HTT P42858 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CDC25A P30304 1/20 0.37
CDC25C P30307 1/20 0.37
RAB9A P51151 3/20 0.37
SIRT2 Q8IXJ6 1/20 0.37
SIRT1 Q96EB6 1/20 0.37
HPRT1 P00492 1/20 0.36
KMT2A Q03164 4/20 0.36
MAPT P10636 4/20 0.36
MEN1 O00255 3/20 0.36
TDP1 Q9NUW8 3/20 0.36
NPC1 O15118 2/20 0.36
GAA P10253 2/20 0.36
NOX1 Q9Y5S8 2/20 0.36
MCL1 Q07820 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19781060 0.82 KIF11 (0.41) KIF11KDM4EHPGDRAB9ASIRT2
SCHEMBL30320191 0.79 CYP2A6 (0.46) ALDH1A1KDM4ERAB9AHPRT1KMT2A
SCHEMBL26612938 0.79 CYP2A6 (0.46) ALDH1A1KDM4ERAB9AHPRT1KMT2A
SCHEMBL29368226 0.78 KIF11 (0.75) KIF11ALDH1A1KDM4EHPGDHTT
SCHEMBL30914261 0.78 KIF11 (0.75) KIF11ALDH1A1KDM4EHPGDHTT
SCHEMBL5466693 0.78 KIF11 (0.75) KIF11ALDH1A1KDM4EHPGDHTT
SCHEMBL19781007 0.78 KIF11 (0.37) KIF11KDM4ERAB9AKMT2AMAPT
SCHEMBL8208687 0.78 HPRT1 (0.54) ALDH1A1HPGDRAB9AHPRT1KMT2A
SCHEMBL19781205 0.76 KIF11 (0.57) KIF11ALDH1A1KDM4EHPGDHTT
SCHEMBL17876528 0.75 KIF11 (0.51) KIF11ALDH1A1KDM4EHPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018012763-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME 주식회사 두산 2018-01-18 WO disclosed