SCHEMBL19781322

SCHEMBL19781322

N#Cc1c(F)cc(C#CSI)cc1F

nearest known ligand 0.45

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21474350 0.76 KDM1A (0.31)
SCHEMBL6649045 0.74 TRPV4 (0.61) TRPV4
SCHEMBL18435121 0.73
SCHEMBL19781243 0.73
SCHEMBL22853322 0.72 GRM5 (0.43)
SCHEMBL19681200 0.72 ACACB (0.38)
SCHEMBL19781320 0.69 TRPV4 (0.45) TRPV4
SCHEMBL22379263 0.69 TRPV4 (0.34) TRPV4
SCHEMBL24942535 0.69 TRPV4 (0.54) TRPV4
SCHEMBL24603484 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10889610-B2 Alpha-D-galactoside inhibitors of galectins GALECTO BIOTECH AB (DK) 2021-01-12 US disclosed
US-20190315793-A1 ALPHA-D-GALACTOSIDE INHIBITORS OF GALECTINS GALECTO BIOTECH AB (DK) 2019-10-17 US disclosed
WO-2018011094-A1 ALPHA-D-GALACTOSIDE INHIBITORS OF GALECTINS GALECTO BIOTECH AB (DK) 2018-01-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190315793-A1 ALPHA-D-GALACTOSIDE INHIBITORS OF GALECTINS LGALS1, LGALS3, LGALS2 TRPV4 4169/4885
US-10889610-B2 Alpha-D-galactoside inhibitors of galectins LGALS1, LGALS3, LGALS2 TRPV4 4169/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.