Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18641909 | 0.89 | L3MBTL1 (0.38) | L3MBTL1KCNJ5IRAK4CYP11B2CYP19A1 | |
| SCHEMBL5796848 | 0.87 | CYP19A1 (0.39) | L3MBTL1KCNJ5CYP11B2CYP19A1 | |
| SCHEMBL7462189 | 0.84 | — | — | |
| SCHEMBL23174810 | 0.81 | IRAK4 (0.39) | IRAK4CYP11B2ARPGREP300 | |
| SCHEMBL1935296 | 0.81 | CYP19A1 (0.34) | CYP11B2CYP19A1ARPGRNLRP3 | |
| SCHEMBL25359893 | 0.81 | L3MBTL1 (0.47) | L3MBTL1KCNJ5IRAK4PIK3CDPIP5K1C | |
| SCHEMBL25362235 | 0.77 | L3MBTL1 (0.44) | L3MBTL1KCNJ5PIK3CDPIP5K1CPIK3CA | |
| SCHEMBL26962749 | 0.77 | NLRP3 (0.39) | L3MBTL1IRAK4CYP11B2CYP19A1AR | |
| SCHEMBL10789578 | 0.76 | — | — | |
| SCHEMBL21265473 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013615-A1 | C7, C12, AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2018-01-18 | — | — | WO | disclosed |