Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.39 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18641909 | 0.95 | L3MBTL1 (0.38) | CYP19A1MGAT2L3MBTL1CYP11B2KDM4E | |
| SCHEMBL19781860 | 0.87 | L3MBTL1 (0.47) | CYP19A1L3MBTL1CYP11B2KCNJ5 | |
| SCHEMBL6249860 | 0.81 | IRAK4 (0.37) | — | |
| SCHEMBL7462189 | 0.80 | — | — | |
| SCHEMBL19986192 | 0.77 | L3MBTL1 (0.38) | L3MBTL1ALDH1A1 | |
| SCHEMBL23174810 | 0.77 | IRAK4 (0.39) | CYP11B2SMN1; SMN2 | |
| SCHEMBL1935296 | 0.77 | CYP19A1 (0.34) | CYP19A1CYP11B2 | |
| SCHEMBL19159122 | 0.74 | LMNA (0.42) | MGAT2L3MBTL1HTTKDRSMN1; SMN2 | |
| SCHEMBL2951930 | 0.73 | L3MBTL1 (0.40) | L3MBTL1KDRSMPD1 | |
| SCHEMBL294214 | 0.73 | LMNA (0.41) | L3MBTL1HTTKDRSMN1; SMN2SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282811-A1 | 4-Cyano-1-aryl-pyrazoles | BAYER AG (DE) | 1988-09-21 | — | — | EP | claimed |
| EP-4346806-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | Biocryst Pharmaceuticals, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117529315-A | Imidazole-containing ALK2 kinase inhibitors | 生物水晶制药公司 | 2024-02-06 | — | — | CN | disclosed |
| WO-2022251188-A2 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | BIOCRYST PHARMACEUTICALS, INC. (US) | 2022-12-01 | — | — | WO | disclosed |
| EP-1308161-B1 | 5-N-heterocyclyl-1-(4-sulfonyl-phenyl)-1H-pyrazole derivatives with cyclooxygenase 2 (COX-2) inhibiting activity for the treatment of inflammatory diseases | PFIZER PROD INC (US) | 2006-01-04 | — | — | EP | disclosed |
| US-4804398-A | 1-aryl-4-cyano-5-halogenopyrazoles, composition containing them, and method of using them as selective herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-14 | — | — | US | disclosed |
| EP-0282811-A1 | 4-Cyano-1-aryl-pyrazoles | BAYER AG (DE) | 1988-09-21 | — | — | EP | disclosed |
| EP-0282811-A1 | 4-Cyano-1-aryl-pyrazoles | BAYER AG (DE) | 1988-09-21 | — | — | EP | disclosed |
| EP-0282811-A1 | 4-Cyano-1-aryl-pyrazoles | BAYER AG (DE) | 1988-09-21 | — | — | EP | disclosed |
| US-4747867-A | 1-aryl-4-cyano-5-halogenopyrazoles, composition containing them, and herbicidal method of using them | BAYER AKTIENGESELLSCHAFT (DE) | 1988-05-31 | — | — | US | disclosed |
| EP-0205021-A2 | 5-Amino-4-cyano-1-pyridyl pyrazoles | BAYER AG (DE) | 1986-12-17 | — | — | EP | disclosed |
| EP-0204242-A2 | 1-Aryl-4-cyano-5-halogen pyrazoles | BAYER AG (DE) | 1986-12-10 | — | — | EP | disclosed |