Sugi Predict

Sugi Predict / Compounds / SCHEMBL19782697

SCHEMBL19782697

SCHEMBL19782697

COc1cnc2c(B3OC(C)(C)C(C)(C)O3)cc(OC)cc2c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SNCA P37840 1/20 0.36
▸ UCHL1 P09936 1/20 0.36
▸ CYP1A1 P04798 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP2E1 P05181 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2C8 P10632 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ CYP2A6 P11509 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ CYP4B1 P13584 1/20 0.33
▸ CYP2B6 P20813 1/20 0.33
▸ CYP3A5 P20815 1/20 0.33
▸ CYP2A7 P20853 1/20 0.33
▸ CYP3A7 P24462 1/20 0.33
▸ CYP2F1 P24903 1/20 0.33
▸ CYP2C18 P33260 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ CYP2J2 P51589 1/20 0.33
▸ CYP4F2 P78329 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30189815 1.00 SNCA (0.36) SNCAUCHL1CYP1A1CYP1A2CYP2E1
SCHEMBL29481805 0.90 SNCA (0.34) SNCAUCHL1CYP1A1CYP1A2CYP2E1
SCHEMBL29481764 0.90 UCHL1 (0.36) SNCAUCHL1BACE2RELA
SCHEMBL19776260 0.90 UCHL1 (0.36) SNCAUCHL1BACE2RELA
SCHEMBL19776061 0.90 SNCA (0.34) SNCAUCHL1CYP1A1CYP1A2CYP2E1
SCHEMBL19776055 0.89 UCHL1 (0.35) SNCAUCHL1BACE2EGFRLIPE
SCHEMBL29481822 0.89 UCHL1 (0.35) SNCAUCHL1BACE2EGFRLIPE
SCHEMBL19776058 0.85 SNCA (0.32) SNCAUCHL1
SCHEMBL29481735 0.85 SNCA (0.32) SNCAUCHL1
SCHEMBL30189807 0.85 HPGDS (0.39) SNCAUCHL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12060347-B2 Bicyclic heteroaryl substituted compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2024-08-13 — — US disclosed
CN-109689647-B Bicyclic heteroaryl substituted compounds 百时美施贵宝公司 2023-01-20 — — CN disclosed
US-20210163465-A1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2021-06-03 — — US disclosed
US-20210163465-A1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2021-06-03 — — US disclosed
EP-3484878-B1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2020-08-19 — — EP disclosed
US-20190292176-A1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BISTOL MYERS SQUIBB COMPANY (US) 2019-09-26 — — US disclosed
US-20190292176-A1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BISTOL MYERS SQUIBB COMPANY (US) 2019-09-26 — — US disclosed
WO-2018013774-A1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2018-01-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12060347-B2 Bicyclic heteroaryl substituted compounds F2, F2RL3, F12 SNCA 1764/4885UCHL1 3815/4885CYP1A1 164/4885
US-20190292176-A1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS F2, F2RL3, PF4 SNCA 2066/4885UCHL1 3513/4885CYP1A1 196/4885
US-20210163465-A1 BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS F2, F2RL3, F12 SNCA 1764/4885UCHL1 3815/4885CYP1A1 164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.