Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 4/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19783269 | 0.81 | IKBKB (0.31) | — | |
| SCHEMBL30189952 | 0.79 | F2RL3 (0.51) | F2RL3MAPTHTTTDP1TP53 | |
| SCHEMBL19782740 | 0.79 | F2RL3 (0.51) | F2RL3MAPTHTTTDP1TP53 | |
| SCHEMBL19783423 | 0.77 | F2RL3 (0.54) | F2RL3 | |
| SCHEMBL19782945 | 0.74 | F2RL3 (0.52) | F2RL3 | |
| SCHEMBL30189754 | 0.72 | HSD17B10 (0.37) | F2RL3MAPTNPC1RAB9AHTT | |
| SCHEMBL19783059 | 0.72 | HSD17B10 (0.37) | F2RL3MAPTNPC1RAB9AHTT | |
| SCHEMBL19783647 | 0.71 | MAPT (0.44) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL21395510 | 0.69 | CA12 (0.45) | HTTLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL30189776 | 0.69 | CA12 (0.45) | HTTLMNACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013774-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |